A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia
The immunosuppressant azathioprine (AZA) is widely used in the treatment of inflammatory bowel disease (IBD) for both inducing and maintaining remission. However, the adverse effects of AZA can often necessitate a dose reduction or discontinuation. Bone marrow suppression is one of the most serious...
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doaj-1fd9568a843c4d0abbadd59477095e332020-11-25T02:36:03ZengKarger PublishersCase Reports in Gastroenterology1662-06312011-07-015234434910.1159/000329707329707A Case of Crohn’s Disease with Improvement after Azathioprine-Induced PancytopeniaYong Sung ChoiJung Pil SuhKee Ho SongJae Bum LeeDoo Seok LeeIn Taek LeeDo Sun KimDoo Han LeeThe immunosuppressant azathioprine (AZA) is widely used in the treatment of inflammatory bowel disease (IBD) for both inducing and maintaining remission. However, the adverse effects of AZA can often necessitate a dose reduction or discontinuation. Bone marrow suppression is one of the most serious complications with AZA treatment. On the other hand, some reports have suggested that neutropenia during AZA therapy reduced the relapse rates of IBD patients, and there have been some cases where eradication of the sensitized leukocytes by leukapheresis or bone marrow transplantation improved the IBD, which may explain the relevant role of neutropenia in controlling disease activity. This report describes the case of a 22-year-old male patient who had Crohn’s colitis and complicated perianal fistulas that required immunosuppression; he achieved endoscopically determined remission and showed accelerated mucosal healing as well as clinical remission following the AZA-induced pancytopenia.http://www.karger.com/Article/FullText/329707PancytopeniaCrohnߣs diseaseImprovement |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Sung Choi Jung Pil Suh Kee Ho Song Jae Bum Lee Doo Seok Lee In Taek Lee Do Sun Kim Doo Han Lee |
spellingShingle |
Yong Sung Choi Jung Pil Suh Kee Ho Song Jae Bum Lee Doo Seok Lee In Taek Lee Do Sun Kim Doo Han Lee A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia Case Reports in Gastroenterology Pancytopenia Crohnߣs disease Improvement |
author_facet |
Yong Sung Choi Jung Pil Suh Kee Ho Song Jae Bum Lee Doo Seok Lee In Taek Lee Do Sun Kim Doo Han Lee |
author_sort |
Yong Sung Choi |
title |
A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia |
title_short |
A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia |
title_full |
A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia |
title_fullStr |
A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia |
title_full_unstemmed |
A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia |
title_sort |
case of crohn’s disease with improvement after azathioprine-induced pancytopenia |
publisher |
Karger Publishers |
series |
Case Reports in Gastroenterology |
issn |
1662-0631 |
publishDate |
2011-07-01 |
description |
The immunosuppressant azathioprine (AZA) is widely used in the treatment of inflammatory bowel disease (IBD) for both inducing and maintaining remission. However, the adverse effects of AZA can often necessitate a dose reduction or discontinuation. Bone marrow suppression is one of the most serious complications with AZA treatment. On the other hand, some reports have suggested that neutropenia during AZA therapy reduced the relapse rates of IBD patients, and there have been some cases where eradication of the sensitized leukocytes by leukapheresis or bone marrow transplantation improved the IBD, which may explain the relevant role of neutropenia in controlling disease activity. This report describes the case of a 22-year-old male patient who had Crohn’s colitis and complicated perianal fistulas that required immunosuppression; he achieved endoscopically determined remission and showed accelerated mucosal healing as well as clinical remission following the AZA-induced pancytopenia. |
topic |
Pancytopenia Crohnߣs disease Improvement |
url |
http://www.karger.com/Article/FullText/329707 |
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