Carbohydrates-based diagnosis, prophylaxis and treatment of infectious diseases: Special emphasis on COVID-19

• Main Authors: Popat S. Kumbhar, Anjali K. Pandya, Arehalli S. Manjappa, John I. Disouza, Vandana B. Patravale
• Format: Article
• Language: English
• Published: Elsevier 2021-12-01
• Series: Carbohydrate Polymer Technologies and Applications
• Subjects: Infectious diseases; COVID-19; SARS-CoV-2; Carbohydrates; Diagnosis; Nanomedicines
• Online Access: http://www.sciencedirect.com/science/article/pii/S2666893921000207

COVID-19 pandemic is taking a dangerous turn due to unavailability of approved and effective vaccines and therapy. Currently available diagnostic techniques are time-consuming, expensive, and maybe impacted by the mutations produced in the virus. Therefore, investigation of novel, rapid, and economic diagnosis techniques, prophylactic vaccines and targeted efficacious drug delivery systems as treatment strategy is imperative. Carbohydrates are essential biomolecules which also act as markers in the realization of immune systems. Moreover, they exhibit antiviral, antimicrobial, and antifungal properties. Carbohydrate-based vaccines and therapeutics including stimuli sensitive systems can be developed successfully and used effectively to fight COVID-19. Thus, carbohydrate-based diagnostic, prophylactic and therapeutic alternatives could be promising to defeat COVID-19 propitiously. Morphology of SARS-CoV-2 and its relevance in devising combat strategies has been discussed. Carbohydrate-based approaches for tackling infectious diseases and their importance in the design of various diagnostic and treatment modalities have been reviewed.