Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer
Objective(s): The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In th...
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doaj-1fde790d89684cbaa2af0996d510aa2d2020-11-24T23:59:37ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742019-06-0122663163610.22038/ijbms.2019.32624.780612582Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancerPeyman Ranji0Shahram Agah1Zahra Heydari2Mohammad Rahmati-Yamchi3Ali Mohammad Alizadeh4Cancer Research Center, Tehran University of Medical Sciences, Tehran, IranColorectal Research Center, Iran University of Medical Sciences, Tehran, IranCancer Research Center, Tehran University of Medical Sciences, Tehran, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical sciences, Tabriz, IranCancer Research Center, Tehran University of Medical Sciences, Tehran, Iran|Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, IranObjective(s): The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we have assessed the impact of L. acidophilus and B. bifidum probiotics on gut bacteria concentration and also their chemo-protective impact on mice colon cancer. In the following, we assessed the effects of these probiotics on the gene expression of vitamin D receptor (VDR) and the leptin receptor (LPR) and the serum biochemical parameters on mice colon cancer. Materials and Methods: Thirty-six male BALB/c mice were equally shared into 4 groups; (i) health with routine dietary foods without any treatment, (ii) azoxymethane (AOM)-induced mice colon cancer with common dietary foods, (iii) and (iv) AOM-induced mice colon cancer with oral consumption of L. acidophilus and B. bifidum (1×109 cfu/g) for 5 months, respectively. Then, the serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), alanine transaminase, alkaline phosphatase, and albumin and also VDR and LPR genes expression were evaluated. Results: Oral consumption of L. acidophilus and B. bifidum probiotics significantly decreased the triglycerides, alkaline phosphatase, LDL, and also the VDR and LPR gene expression in mice colon cancer (Phttp://ijbms.mums.ac.ir/article_12582_e079eecb9e4238dcab3558261d90c7e1.pdfColon cancerLeptin receptorMiceProbioticVitamin D Receptor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peyman Ranji Shahram Agah Zahra Heydari Mohammad Rahmati-Yamchi Ali Mohammad Alizadeh |
spellingShingle |
Peyman Ranji Shahram Agah Zahra Heydari Mohammad Rahmati-Yamchi Ali Mohammad Alizadeh Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer Iranian Journal of Basic Medical Sciences Colon cancer Leptin receptor Mice Probiotic Vitamin D Receptor |
author_facet |
Peyman Ranji Shahram Agah Zahra Heydari Mohammad Rahmati-Yamchi Ali Mohammad Alizadeh |
author_sort |
Peyman Ranji |
title |
Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer |
title_short |
Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer |
title_full |
Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer |
title_fullStr |
Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer |
title_full_unstemmed |
Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer |
title_sort |
effects of lactobacillus acidophilus and bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin d and leptin receptor genes on mice colon cancer |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Basic Medical Sciences |
issn |
2008-3866 2008-3874 |
publishDate |
2019-06-01 |
description |
Objective(s): The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we have assessed the impact of L. acidophilus and B. bifidum probiotics on gut bacteria concentration and also their chemo-protective impact on mice colon cancer. In the following, we assessed the effects of these probiotics on the gene expression of vitamin D receptor (VDR) and the leptin receptor (LPR) and the serum biochemical parameters on mice colon cancer. Materials and Methods: Thirty-six male BALB/c mice were equally shared into 4 groups; (i) health with routine dietary foods without any treatment, (ii) azoxymethane (AOM)-induced mice colon cancer with common dietary foods, (iii) and (iv) AOM-induced mice colon cancer with oral consumption of L. acidophilus and B. bifidum (1×109 cfu/g) for 5 months, respectively. Then, the serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), alanine transaminase, alkaline phosphatase, and albumin and also VDR and LPR genes expression were evaluated. Results: Oral consumption of L. acidophilus and B. bifidum probiotics significantly decreased the triglycerides, alkaline phosphatase, LDL, and also the VDR and LPR gene expression in mice colon cancer (P |
topic |
Colon cancer Leptin receptor Mice Probiotic Vitamin D Receptor |
url |
http://ijbms.mums.ac.ir/article_12582_e079eecb9e4238dcab3558261d90c7e1.pdf |
work_keys_str_mv |
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