Polymeric composite devices for localized treatment of early-stage breast cancer.
For early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based...
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doaj-1fdeb57ebbcd41948c4fa58773e381c12020-11-25T01:58:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017254210.1371/journal.pone.0172542Polymeric composite devices for localized treatment of early-stage breast cancer.Kwabena Kan-DapaahNima RahbarWole SoboyejoFor early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based methods have been developed, residual cells are found in 20-55% of the time at the first operation. Furthermore, some current treatment methods result in poor cosmesis. For the last decade, the authors have been exploring the use of polymeric composite materials in single and multi-modal implantable biomedical devices for post-operative treatment of breast cancer. In this paper, the concept and working principles of the devices, as well as selected results from experimental and numerical investigations, are presented. The results show the potential of the biomedical implants for cancer treatment.http://europepmc.org/articles/PMC5330467?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kwabena Kan-Dapaah Nima Rahbar Wole Soboyejo |
spellingShingle |
Kwabena Kan-Dapaah Nima Rahbar Wole Soboyejo Polymeric composite devices for localized treatment of early-stage breast cancer. PLoS ONE |
author_facet |
Kwabena Kan-Dapaah Nima Rahbar Wole Soboyejo |
author_sort |
Kwabena Kan-Dapaah |
title |
Polymeric composite devices for localized treatment of early-stage breast cancer. |
title_short |
Polymeric composite devices for localized treatment of early-stage breast cancer. |
title_full |
Polymeric composite devices for localized treatment of early-stage breast cancer. |
title_fullStr |
Polymeric composite devices for localized treatment of early-stage breast cancer. |
title_full_unstemmed |
Polymeric composite devices for localized treatment of early-stage breast cancer. |
title_sort |
polymeric composite devices for localized treatment of early-stage breast cancer. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
For early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based methods have been developed, residual cells are found in 20-55% of the time at the first operation. Furthermore, some current treatment methods result in poor cosmesis. For the last decade, the authors have been exploring the use of polymeric composite materials in single and multi-modal implantable biomedical devices for post-operative treatment of breast cancer. In this paper, the concept and working principles of the devices, as well as selected results from experimental and numerical investigations, are presented. The results show the potential of the biomedical implants for cancer treatment. |
url |
http://europepmc.org/articles/PMC5330467?pdf=render |
work_keys_str_mv |
AT kwabenakandapaah polymericcompositedevicesforlocalizedtreatmentofearlystagebreastcancer AT nimarahbar polymericcompositedevicesforlocalizedtreatmentofearlystagebreastcancer AT wolesoboyejo polymericcompositedevicesforlocalizedtreatmentofearlystagebreastcancer |
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1724968576120520704 |