Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

While the affinities and specificities of SH2 domain-phosphotyrosine interactions have been well characterized, spatio-temporal changes in phosphosite availability in response to signals, and their impact on recruitment of SH2-containing proteins in vivo, are not well understood. To address this iss...

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Bibliographic Details
Main Authors: Joshua A Jadwin, Dongmyung Oh, Timothy G Curran, Mari Ogiue-Ikeda, Lin Jia, Forest M White, Kazuya Machida, Ji Yu, Bruce J Mayer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
receptor tyrosine kinase
signal transduction
SH2 domain
Online Access:https://elifesciences.org/articles/11835

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