Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall
Perivascular epithelioid cell tumors (PEComas) are a family of rare mesenchymal tumors with discrete histological and immunohistochemical characteristics. Even rarer among them are cutaneous and subcutaneous PEComas. We describe a 34-year-old woman who presented with a large anterior abdominal subcu...
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doaj-1fe7dfdbcbaa4054b224f37913085ecf2021-03-23T04:34:02ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042021-03-01362e239e23910.5001/omj.2021.21Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal WallDavid Eng Yeow Gan0Rebecca Xin Yi Choy1Harivinthan Sellappan2Firdaus Hayati3Nornazirah Azizan44Department of Surgery, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia; Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur, MalaysiaDepartment of Surgery, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Sabah, MalaysiaDepartment of Surgery, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Sabah, MalaysiaDepartment of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia Department of Pathobiology and Medical Diagnostic, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, MalaysiaPerivascular epithelioid cell tumors (PEComas) are a family of rare mesenchymal tumors with discrete histological and immunohistochemical characteristics. Even rarer among them are cutaneous and subcutaneous PEComas. We describe a 34-year-old woman who presented with a large anterior abdominal subcutaneous lesion showing intact overlying skin and no obvious invasion of the abdominal musculature. A wide local excision was performed. Histopathology revealed a solitary tumor measuring 75 × 55 × 90 mm with epithelioid cells in nests with thin fibrovascular septa and spindle cells. Resection margins were clear with no invasion to the skin or rectus sheath. Tumor cells were positive for HMB-45 but negative for other markers. This is the largest subcutaneous PEComa reported to date.http://omjournal.org/articleDetails.aspx?coType=1&aId=2871epithelioid cellsperivascular epithelioid cell neoplasms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David Eng Yeow Gan Rebecca Xin Yi Choy Harivinthan Sellappan Firdaus Hayati Nornazirah Azizan4 |
spellingShingle |
David Eng Yeow Gan Rebecca Xin Yi Choy Harivinthan Sellappan Firdaus Hayati Nornazirah Azizan4 Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall Oman Medical Journal epithelioid cells perivascular epithelioid cell neoplasms |
author_facet |
David Eng Yeow Gan Rebecca Xin Yi Choy Harivinthan Sellappan Firdaus Hayati Nornazirah Azizan4 |
author_sort |
David Eng Yeow Gan |
title |
Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall |
title_short |
Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall |
title_full |
Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall |
title_fullStr |
Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall |
title_full_unstemmed |
Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall |
title_sort |
malignant subcutaneous perivascular epithelioid cell tumor of anterior abdominal wall |
publisher |
Oman Medical Specialty Board |
series |
Oman Medical Journal |
issn |
1999-768X 2070-5204 |
publishDate |
2021-03-01 |
description |
Perivascular epithelioid cell tumors (PEComas) are a family of rare mesenchymal tumors with discrete histological and immunohistochemical characteristics. Even rarer among them are cutaneous and subcutaneous PEComas. We describe a 34-year-old woman who presented with a large anterior abdominal subcutaneous lesion showing intact overlying skin and no obvious invasion of the abdominal musculature. A wide local excision was performed. Histopathology revealed a solitary tumor measuring 75 × 55 × 90 mm with epithelioid cells in nests with thin fibrovascular septa and spindle cells. Resection margins were clear with no invasion to the skin or rectus sheath. Tumor cells were positive for HMB-45 but negative for other markers. This is the largest subcutaneous PEComa reported to date. |
topic |
epithelioid cells perivascular epithelioid cell neoplasms |
url |
http://omjournal.org/articleDetails.aspx?coType=1&aId=2871 |
work_keys_str_mv |
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