ApoE4 attenuates autophagy via FoxO3a repression in the brain
Abstract Apolipoprotein E (ApoE) plays multiple roles in lipid transport, neuronal signaling, glucose metabolism, mitochondrial function, and inflammation in the brain. It is also associated with neurodegenerative diseases, and its influence differs depending on the isoform. In particular, the ε4 al...
Main Authors: | Hee-Young Sohn, Seong-Ik Kim, Jee-Yun Park, Sung-Hye Park, Young Ho Koh, Joon Kim, Chulman Jo |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-09-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-97117-6 |
Similar Items
-
FoxO1 in the regulation of adipocyte autophagy and biology
by: Liu, Longhua
Published: (2016) -
Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351
by: Jee-Yun Park, et al.
Published: (2021-04-01) -
The potential role of FoxO transcription factor during postembryonic periods in the silkworm, Bombyx mori (Lepidoptera: Bombycidae)
by: Jin Kim HEE, et al.
Published: (2012-07-01) -
FoxO1-mediated autophagy is required for NK cell development and innate immunity
by: Shuo Wang, et al.
Published: (2016-03-01) -
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
by: Khanh V. Doan, et al.
Published: (2016-09-01)