Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses
Mesenchymal stromal cells (MSCs) are adult progenitor cells with a high migratory and differentiation potential, which influence a broad range of biological functions in almost every tissue of the body. Among other mechanisms, MSCs do so by the secretion of molecular cues, differentiation toward mor...
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doaj-1ff276e295514d6babe8681ffb977d0c2021-09-05T20:51:10ZengDe GruyterInnovative Surgical Science2364-74852016-09-0111193210.1515/iss-2016-0005iss-2016-0005Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horsesNiess Hanno0Thomas Michael N.1Schiergens Tobias S.2Kleespies Axel3Jauch Karl-Walter4Bruns Christiane5Werner Jens6Nelson Peter J.7Angele Martin K.8Department of General, Visceral, Transplantation and Vascular Surgery, Hospital of the University of Munich, Munich, GermanyDepartment of General, Visceral, Transplantation and Vascular Surgery, Hospital of the University of Munich, Munich, GermanyDepartment of General, Visceral, Transplantation and Vascular Surgery, Hospital of the University of Munich, Munich, GermanyDepartment of General, Visceral, Transplantation and Vascular Surgery, Hospital of the University of Munich, Munich, GermanyDepartment of General, Visceral, Transplantation and Vascular Surgery, Hospital of the University of Munich, Munich, GermanyDepartment of General, Visceral and Cancer Surgery, Hospital of the University of Cologne, Cologne, GermanyDepartment of General, Visceral, Transplantation and Vascular Surgery, Hospital of the University of Munich, Munich, GermanyMedizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universitaet Muenchen, Arbeitsgruppe Klinische Biochemie, Munich, GermanyDepartment of General, Visceral, Transplantation and Vascular Surgery, Hospital of the University of Munich, Munich, GermanyMesenchymal stromal cells (MSCs) are adult progenitor cells with a high migratory and differentiation potential, which influence a broad range of biological functions in almost every tissue of the body. Among other mechanisms, MSCs do so by the secretion of molecular cues, differentiation toward more specialized cell types, or influence on the immune system. Expanding tumors also depend on the contribution of MSCs to building a supporting stroma, but the effects of MSCs appear to go beyond the mere supply of connective tissues. MSCs show targeted “homing” toward growing tumors, which is then followed by exerting direct and indirect effects on cancer cells. Several research groups have developed novel strategies that make use of the tumor tropism of MSCs by engineering them to express a transgene that enables an attack on cancer growth. This review aims to familiarize the reader with the current knowledge about MSC biology, the existing evidence for MSC contribution to tumor growth with its underlying mechanisms, and the strategies that have been developed using MSCs to deploy an anticancer therapy.https://doi.org/10.1515/iss-2016-0005hsv-tkmesenchymal stromal cellsmscsuicide gene therapytumor stroma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Niess Hanno Thomas Michael N. Schiergens Tobias S. Kleespies Axel Jauch Karl-Walter Bruns Christiane Werner Jens Nelson Peter J. Angele Martin K. |
spellingShingle |
Niess Hanno Thomas Michael N. Schiergens Tobias S. Kleespies Axel Jauch Karl-Walter Bruns Christiane Werner Jens Nelson Peter J. Angele Martin K. Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses Innovative Surgical Science hsv-tk mesenchymal stromal cells msc suicide gene therapy tumor stroma |
author_facet |
Niess Hanno Thomas Michael N. Schiergens Tobias S. Kleespies Axel Jauch Karl-Walter Bruns Christiane Werner Jens Nelson Peter J. Angele Martin K. |
author_sort |
Niess Hanno |
title |
Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses |
title_short |
Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses |
title_full |
Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses |
title_fullStr |
Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses |
title_full_unstemmed |
Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses |
title_sort |
genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into trojan horses |
publisher |
De Gruyter |
series |
Innovative Surgical Science |
issn |
2364-7485 |
publishDate |
2016-09-01 |
description |
Mesenchymal stromal cells (MSCs) are adult progenitor cells with a high migratory and differentiation potential, which influence a broad range of biological functions in almost every tissue of the body. Among other mechanisms, MSCs do so by the secretion of molecular cues, differentiation toward more specialized cell types, or influence on the immune system. Expanding tumors also depend on the contribution of MSCs to building a supporting stroma, but the effects of MSCs appear to go beyond the mere supply of connective tissues. MSCs show targeted “homing” toward growing tumors, which is then followed by exerting direct and indirect effects on cancer cells. Several research groups have developed novel strategies that make use of the tumor tropism of MSCs by engineering them to express a transgene that enables an attack on cancer growth. This review aims to familiarize the reader with the current knowledge about MSC biology, the existing evidence for MSC contribution to tumor growth with its underlying mechanisms, and the strategies that have been developed using MSCs to deploy an anticancer therapy. |
topic |
hsv-tk mesenchymal stromal cells msc suicide gene therapy tumor stroma |
url |
https://doi.org/10.1515/iss-2016-0005 |
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