Development of background-free tame fluorescent probes for intracellular live cell imaging

The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.

Bibliographic Details
Main Authors:	Samira Husen Alamudi, Rudrakanta Satapathy, Jihyo Kim, Dongdong Su, Haiyan Ren, Rajkumar Das, Lingna Hu, Enrique Alvarado-Martínez, Jung Yeol Lee, Christian Hoppmann, Eduardo Peña-Cabrera, Hyung-Ho Ha, Hee-Sung Park, Lei Wang, Young-Tae Chang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11964

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spelling	doaj-1ffa76b518c2484e9d9435cbbf2eabe72021-05-11T10:58:05ZengNature Publishing GroupNature Communications2041-17232016-06-01711910.1038/ncomms11964Development of background-free tame fluorescent probes for intracellular live cell imagingSamira Husen Alamudi0Rudrakanta Satapathy1Jihyo Kim2Dongdong Su3Haiyan Ren4Rajkumar Das5Lingna Hu6Enrique Alvarado-Martínez7Jung Yeol Lee8Christian Hoppmann9Eduardo Peña-Cabrera10Hyung-Ho Ha11Hee-Sung Park12Lei Wang13Young-Tae Chang14Department of Chemistry & Med Chem Program, National University of SingaporeDepartment of Chemistry & Med Chem Program, National University of SingaporeDepartment of Chemistry, Korea Advanced Institute of Science and TechnologyLaboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and ResearchDepartment of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of CaliforniaDepartment of Chemistry & Med Chem Program, National University of SingaporeDepartment of Chemistry & Med Chem Program, National University of SingaporeDepartamento de Química, Universidad de GuanajuatoDepartment of Chemistry & Med Chem Program, National University of SingaporeDepartment of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of CaliforniaDepartamento de Química, Universidad de GuanajuatoCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National UniversityDepartment of Chemistry, Korea Advanced Institute of Science and TechnologyDepartment of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of CaliforniaDepartment of Chemistry & Med Chem Program, National University of SingaporeThe success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.https://doi.org/10.1038/ncomms11964
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Samira Husen Alamudi Rudrakanta Satapathy Jihyo Kim Dongdong Su Haiyan Ren Rajkumar Das Lingna Hu Enrique Alvarado-Martínez Jung Yeol Lee Christian Hoppmann Eduardo Peña-Cabrera Hyung-Ho Ha Hee-Sung Park Lei Wang Young-Tae Chang
spellingShingle	Samira Husen Alamudi Rudrakanta Satapathy Jihyo Kim Dongdong Su Haiyan Ren Rajkumar Das Lingna Hu Enrique Alvarado-Martínez Jung Yeol Lee Christian Hoppmann Eduardo Peña-Cabrera Hyung-Ho Ha Hee-Sung Park Lei Wang Young-Tae Chang Development of background-free tame fluorescent probes for intracellular live cell imaging Nature Communications
author_facet	Samira Husen Alamudi Rudrakanta Satapathy Jihyo Kim Dongdong Su Haiyan Ren Rajkumar Das Lingna Hu Enrique Alvarado-Martínez Jung Yeol Lee Christian Hoppmann Eduardo Peña-Cabrera Hyung-Ho Ha Hee-Sung Park Lei Wang Young-Tae Chang
author_sort	Samira Husen Alamudi
title	Development of background-free tame fluorescent probes for intracellular live cell imaging
title_short	Development of background-free tame fluorescent probes for intracellular live cell imaging
title_full	Development of background-free tame fluorescent probes for intracellular live cell imaging
title_fullStr	Development of background-free tame fluorescent probes for intracellular live cell imaging
title_full_unstemmed	Development of background-free tame fluorescent probes for intracellular live cell imaging
title_sort	development of background-free tame fluorescent probes for intracellular live cell imaging
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-06-01
description	The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.
url	https://doi.org/10.1038/ncomms11964
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Development of background-free tame fluorescent probes for intracellular live cell imaging

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