Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats
Background: Resistance exercise effects on cardiovascular parameters are not consistent. Objectives: The effects of resistance exercise on changes in blood glucose, blood pressure and vascular reactivity were evaluated in diabetic rats. Methods: Wistar rats were divided into three groups: contro...
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Sociedade Brasileira de Cardiologia (SBC)
2014-07-01
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doaj-1ffb28fb35c54ba4b0330507e6f834002020-11-25T01:58:12ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-41702014-07-011031253210.5935/abc.20140087S0066-782X2014001900005Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic RatsMarcelo Mendonça MotaTharciano Luiz Teixeira Braga da SilvaMilene Tavares FontesAndré Sales BarretoJoão Eliakim dos Santos AraújoAntônio Cesar Cabral de OliveiraRogério Brandão WichiMárcio Roberto Viana SantosBackground: Resistance exercise effects on cardiovascular parameters are not consistent. Objectives: The effects of resistance exercise on changes in blood glucose, blood pressure and vascular reactivity were evaluated in diabetic rats. Methods: Wistar rats were divided into three groups: control group (n = 8); sedentary diabetic (n = 8); and trained diabetic (n = 8). Resistance exercise was carried out in a squat device for rats and consisted of three sets of ten repetitions with an intensity of 50%, three times per week, for eight weeks. Changes in vascular reactivity were evaluated in superior mesenteric artery rings. Results: A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency. In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group. Furthermore, a significant increase (p < 0.05) in mean arterial blood pressure was observed in the sedentary diabetic group (104.9 ± 5 to 126.7 ± 5 mmHg) as compared to that in the control group. However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group. Conclusions: Resistance exercise could restore endothelial function and prevent an increase in arterial blood pressure in type 1 diabetic rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2014001900005&lng=en&tlng=enRatosExercícioResistência FísicaEndotélio Vascular / fisiologiaPressão Arterial / fisiologiaDiabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcelo Mendonça Mota Tharciano Luiz Teixeira Braga da Silva Milene Tavares Fontes André Sales Barreto João Eliakim dos Santos Araújo Antônio Cesar Cabral de Oliveira Rogério Brandão Wichi Márcio Roberto Viana Santos |
spellingShingle |
Marcelo Mendonça Mota Tharciano Luiz Teixeira Braga da Silva Milene Tavares Fontes André Sales Barreto João Eliakim dos Santos Araújo Antônio Cesar Cabral de Oliveira Rogério Brandão Wichi Márcio Roberto Viana Santos Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats Arquivos Brasileiros de Cardiologia Ratos Exercício Resistência Física Endotélio Vascular / fisiologia Pressão Arterial / fisiologia Diabetes |
author_facet |
Marcelo Mendonça Mota Tharciano Luiz Teixeira Braga da Silva Milene Tavares Fontes André Sales Barreto João Eliakim dos Santos Araújo Antônio Cesar Cabral de Oliveira Rogério Brandão Wichi Márcio Roberto Viana Santos |
author_sort |
Marcelo Mendonça Mota |
title |
Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats |
title_short |
Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats |
title_full |
Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats |
title_fullStr |
Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats |
title_full_unstemmed |
Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats |
title_sort |
resistance exercise restores endothelial function and reduces blood pressure in type 1 diabetic rats |
publisher |
Sociedade Brasileira de Cardiologia (SBC) |
series |
Arquivos Brasileiros de Cardiologia |
issn |
1678-4170 |
publishDate |
2014-07-01 |
description |
Background: Resistance exercise effects on cardiovascular parameters are not consistent. Objectives: The effects of resistance exercise on changes in blood glucose, blood pressure and vascular reactivity were evaluated in diabetic rats. Methods: Wistar rats were divided into three groups: control group (n = 8); sedentary diabetic (n = 8); and trained diabetic (n = 8). Resistance exercise was carried out in a squat device for rats and consisted of three sets of ten repetitions with an intensity of 50%, three times per week, for eight weeks. Changes in vascular reactivity were evaluated in superior mesenteric artery rings. Results: A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency. In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group. Furthermore, a significant increase (p < 0.05) in mean arterial blood pressure was observed in the sedentary diabetic group (104.9 ± 5 to 126.7 ± 5 mmHg) as compared to that in the control group. However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group. Conclusions: Resistance exercise could restore endothelial function and prevent an increase in arterial blood pressure in type 1 diabetic rats. |
topic |
Ratos Exercício Resistência Física Endotélio Vascular / fisiologia Pressão Arterial / fisiologia Diabetes |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2014001900005&lng=en&tlng=en |
work_keys_str_mv |
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