Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy
Purpose: This study aimed to identify consistent gray matter volume (GMV) changes in the two subtypes of multiple system atrophy (MSA), including parkinsonism subtype (MSA-P), and cerebellar subtype (MSA-C), by conducting a voxel-wise meta-analysis of whole brain voxel-based morphometry (VBM) studie...
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doaj-200478c13ac74513a8543aa53bb1930b2020-12-08T08:40:57ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-11-011210.3389/fnagi.2020.591666591666Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System AtrophyJunyu LinXinran XuYanbing HouJing YangHuifang ShangPurpose: This study aimed to identify consistent gray matter volume (GMV) changes in the two subtypes of multiple system atrophy (MSA), including parkinsonism subtype (MSA-P), and cerebellar subtype (MSA-C), by conducting a voxel-wise meta-analysis of whole brain voxel-based morphometry (VBM) studies.Method: VBM studies comparing MSA-P or MSA-C and healthy controls (HCs) were systematically searched in the PubMed, Embase, and Web of Science published from 1974 to 20 October 2020. A quantitative meta-analysis of VBM studies on MSA-P or MSA-C was performed using the effect size-based signed differential mapping (ES-SDM) method separately. A complementary analysis was conducted using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) method, which allows a familywise error rate (FWE) correction for multiple comparisons of the results, for further validation of the results.Results: Ten studies were included in the meta-analysis of MSA-P subtype, comprising 136 MSA-P patients and 211 HCs. Five studies were included in the meta-analysis of MSA-C subtype, comprising 89 MSA-C patients and 134 HCs. Cerebellum atrophy was detected in both MSA-P and MSA-C, whereas basal ganglia atrophy was only detected in MSA-P. Cerebral cortex atrophy was detected in both subtypes, with predominant impairment of the superior temporal gyrus, inferior frontal gyrus, temporal pole, insula, and amygdala in MSA-P and predominant impairment of the superior temporal gyrus, middle temporal gyrus, fusiform gyrus, and lingual gyrus in MSA-C. Most of these results survived the FWE correction in the complementary analysis, except for the bilateral amygdala and the left caudate nucleus in MSA-P, and the right superior temporal gyrus and the right middle temporal gyrus in MSA-C. These findings remained robust in the jackknife sensitivity analysis, and no significant heterogeneity was detected.Conclusion: A different pattern of brain atrophy between MSA-P and MSA-C detected in the current study was in line with clinical manifestations and provided the evidence of the pathophysiology of the two subtypes of MSA.https://www.frontiersin.org/articles/10.3389/fnagi.2020.591666/fullmultiple system atrophyvoxel-based morphometrygray matter volumemeta-analysissubtype |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junyu Lin Xinran Xu Yanbing Hou Jing Yang Huifang Shang |
spellingShingle |
Junyu Lin Xinran Xu Yanbing Hou Jing Yang Huifang Shang Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy Frontiers in Aging Neuroscience multiple system atrophy voxel-based morphometry gray matter volume meta-analysis subtype |
author_facet |
Junyu Lin Xinran Xu Yanbing Hou Jing Yang Huifang Shang |
author_sort |
Junyu Lin |
title |
Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy |
title_short |
Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy |
title_full |
Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy |
title_fullStr |
Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy |
title_full_unstemmed |
Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy |
title_sort |
voxel-based meta-analysis of gray matter abnormalities in multiple system atrophy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2020-11-01 |
description |
Purpose: This study aimed to identify consistent gray matter volume (GMV) changes in the two subtypes of multiple system atrophy (MSA), including parkinsonism subtype (MSA-P), and cerebellar subtype (MSA-C), by conducting a voxel-wise meta-analysis of whole brain voxel-based morphometry (VBM) studies.Method: VBM studies comparing MSA-P or MSA-C and healthy controls (HCs) were systematically searched in the PubMed, Embase, and Web of Science published from 1974 to 20 October 2020. A quantitative meta-analysis of VBM studies on MSA-P or MSA-C was performed using the effect size-based signed differential mapping (ES-SDM) method separately. A complementary analysis was conducted using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) method, which allows a familywise error rate (FWE) correction for multiple comparisons of the results, for further validation of the results.Results: Ten studies were included in the meta-analysis of MSA-P subtype, comprising 136 MSA-P patients and 211 HCs. Five studies were included in the meta-analysis of MSA-C subtype, comprising 89 MSA-C patients and 134 HCs. Cerebellum atrophy was detected in both MSA-P and MSA-C, whereas basal ganglia atrophy was only detected in MSA-P. Cerebral cortex atrophy was detected in both subtypes, with predominant impairment of the superior temporal gyrus, inferior frontal gyrus, temporal pole, insula, and amygdala in MSA-P and predominant impairment of the superior temporal gyrus, middle temporal gyrus, fusiform gyrus, and lingual gyrus in MSA-C. Most of these results survived the FWE correction in the complementary analysis, except for the bilateral amygdala and the left caudate nucleus in MSA-P, and the right superior temporal gyrus and the right middle temporal gyrus in MSA-C. These findings remained robust in the jackknife sensitivity analysis, and no significant heterogeneity was detected.Conclusion: A different pattern of brain atrophy between MSA-P and MSA-C detected in the current study was in line with clinical manifestations and provided the evidence of the pathophysiology of the two subtypes of MSA. |
topic |
multiple system atrophy voxel-based morphometry gray matter volume meta-analysis subtype |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2020.591666/full |
work_keys_str_mv |
AT junyulin voxelbasedmetaanalysisofgraymatterabnormalitiesinmultiplesystematrophy AT xinranxu voxelbasedmetaanalysisofgraymatterabnormalitiesinmultiplesystematrophy AT yanbinghou voxelbasedmetaanalysisofgraymatterabnormalitiesinmultiplesystematrophy AT jingyang voxelbasedmetaanalysisofgraymatterabnormalitiesinmultiplesystematrophy AT huifangshang voxelbasedmetaanalysisofgraymatterabnormalitiesinmultiplesystematrophy |
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1724390376315289600 |