Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy
Background: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a fatal and common clinical disorder in critically ill patients. Recent studies have shown that the relationship between BMI and the outcome of patients with AKI undergoing CRRT is conflicting. Methods: A...
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doaj-2007ecbd39db42528df899489ccdb28e2021-06-02T08:05:29ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492019-01-0141172673210.1080/0886022X.2019.16507671650767Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapyHai Wang0Yu Shi1Zheng-Hai Bai2Jun-Hua Lv3Jiang-Li Sun4Hong-Hong Pei5Zheng-Liang Zhang6The Second Affiliated Hospital of Xi’an Jiaotong UniversityThe Second Affiliated Hospital of Xi’an Jiaotong UniversityThe Second Affiliated Hospital of Xi’an Jiaotong UniversityThe Second Affiliated Hospital of Xi’an Jiaotong UniversityThe Second Affiliated Hospital of Xi’an Jiaotong UniversityThe Second Affiliated Hospital of Xi’an Jiaotong UniversityThe Second Affiliated Hospital of Xi’an Jiaotong UniversityBackground: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a fatal and common clinical disorder in critically ill patients. Recent studies have shown that the relationship between BMI and the outcome of patients with AKI undergoing CRRT is conflicting. Methods: A retrospective cohort study based on data reuse. Univariate analysis, multi-factor regression analysis and subgroup analyses were used to explore the association of the BMI with the 28-days mortality risk in patients with AKI undergoing CRRT. Results: From January 2009 to September 2016, a total of 1120 cases met the inclusion criteria and were enrolled in this study. The univariate analysis showed that BMI was associated with 28-days mortality of patients with AKI undergoing CRRT, its HR value was 0.98 (0.96, 0.99). The multi-factor regression analysis showed that BMI was not associated with 28-days mortality of patients with AKI undergoing CRRT in the four models, the adjusted HR value of four models were 1.00 (0.96, 1.04), 1.01 (0.97, 1.04), 1.00 (0.96, 1.04) and 1.00 (0.96, 1.04), respectively. The subgroups analyses showed that the BMI was a risk factor of the 28-days mortality in patients with AKI undergoing CRRT when GFR ≥30 mL/min, its HR value was 1.04 (1.01, 1.09). Conclusion: Higher BMI was not a protective risk of 28-day mortality in patients with AKI undergoing CRRT. Especially, when GFR ≥30 mL/min, higher BMI increased the risk of the 28-day mortality rate in patients with AKI undergoing CRRT.http://dx.doi.org/10.1080/0886022X.2019.1650767body mass indexacute kidney injurycontinuous renal replacement therapy28-day mortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hai Wang Yu Shi Zheng-Hai Bai Jun-Hua Lv Jiang-Li Sun Hong-Hong Pei Zheng-Liang Zhang |
spellingShingle |
Hai Wang Yu Shi Zheng-Hai Bai Jun-Hua Lv Jiang-Li Sun Hong-Hong Pei Zheng-Liang Zhang Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy Renal Failure body mass index acute kidney injury continuous renal replacement therapy 28-day mortality |
author_facet |
Hai Wang Yu Shi Zheng-Hai Bai Jun-Hua Lv Jiang-Li Sun Hong-Hong Pei Zheng-Liang Zhang |
author_sort |
Hai Wang |
title |
Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy |
title_short |
Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy |
title_full |
Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy |
title_fullStr |
Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy |
title_full_unstemmed |
Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy |
title_sort |
higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy |
publisher |
Taylor & Francis Group |
series |
Renal Failure |
issn |
0886-022X 1525-6049 |
publishDate |
2019-01-01 |
description |
Background: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a fatal and common clinical disorder in critically ill patients. Recent studies have shown that the relationship between BMI and the outcome of patients with AKI undergoing CRRT is conflicting. Methods: A retrospective cohort study based on data reuse. Univariate analysis, multi-factor regression analysis and subgroup analyses were used to explore the association of the BMI with the 28-days mortality risk in patients with AKI undergoing CRRT. Results: From January 2009 to September 2016, a total of 1120 cases met the inclusion criteria and were enrolled in this study. The univariate analysis showed that BMI was associated with 28-days mortality of patients with AKI undergoing CRRT, its HR value was 0.98 (0.96, 0.99). The multi-factor regression analysis showed that BMI was not associated with 28-days mortality of patients with AKI undergoing CRRT in the four models, the adjusted HR value of four models were 1.00 (0.96, 1.04), 1.01 (0.97, 1.04), 1.00 (0.96, 1.04) and 1.00 (0.96, 1.04), respectively. The subgroups analyses showed that the BMI was a risk factor of the 28-days mortality in patients with AKI undergoing CRRT when GFR ≥30 mL/min, its HR value was 1.04 (1.01, 1.09). Conclusion: Higher BMI was not a protective risk of 28-day mortality in patients with AKI undergoing CRRT. Especially, when GFR ≥30 mL/min, higher BMI increased the risk of the 28-day mortality rate in patients with AKI undergoing CRRT. |
topic |
body mass index acute kidney injury continuous renal replacement therapy 28-day mortality |
url |
http://dx.doi.org/10.1080/0886022X.2019.1650767 |
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