Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo
Vitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with gene...
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University of Belgrade, University of Novi Sad
2019-01-01
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doaj-2008ada3d38f44d49a59439e6ae741562020-11-25T02:44:10ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392019-01-01711556210.2298/ABS181003047P0354-46641800047PDynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligoPektaş Gökhan0Pektaş Suzan Demir1Öztekin Aynure2Oztekin Coşkun3Neşelioglu Salim4Erel Özcan5Sadi Gökhan6Mugla Sitki Kocman University Training and Research Hospital, Department of Hematology, Mugla, TurkeyMugla Sitki Kocman University, Faculty of Medicine, Department of Dermatology, Mugla, TurkeyHitit University, Faculty of Medicine, Department of Dermatology, Corum, TurkeyHitit University, Faculty of Medicine, Department of Family Medicine, Corum, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Biochemistry, Ankara, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Biochemistry, Ankara, TurkeyKaramanoğlu Mehmetbey University, K.Ö. Science Faculty, Department of Biology, Karaman, TurkeyVitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with generalized vitiligo and to determine its relationship with some of the demographical characteristics. Seventy-six generalized vitiligo patients and 67 healthy individuals were included in the study. Blood serum native thiol, disulfide and total thiol concentrations, together with some hematological parameters, were determined. Results demonstrated that native and total thiol contents, and their ratios, were significantly lower in vitiligo patients. Disulfide/native thiol and disulfide/total thiol ratios were significantly higher in the patient group. Progressivity of the disease strongly regulated the thiol/disulfide homeostasis in such a way that active vitiligo patients had reduced native and total thiol levels but increased disulfide/native thiol and disulfide/total thiol ratios. Moreover, there was a statistically significant negative correlation between both duration of the vitiligo and native and total thiol contents. As these results clearly demonstrated that thiol/disulfide homeostasis was shifted toward disulfide formation in patients with generalized vitiligo, determining the dynamic nature of thiol/disulfide homeostasis can be used to monitor disease progression.http://www.doiserbia.nb.rs/img/doi/0354-4664/2019/0354-46641800047P.pdfgeneralized vitiligonative thioldisulfidetotal thiolhomeostasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pektaş Gökhan Pektaş Suzan Demir Öztekin Aynure Oztekin Coşkun Neşelioglu Salim Erel Özcan Sadi Gökhan |
spellingShingle |
Pektaş Gökhan Pektaş Suzan Demir Öztekin Aynure Oztekin Coşkun Neşelioglu Salim Erel Özcan Sadi Gökhan Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo Archives of Biological Sciences generalized vitiligo native thiol disulfide total thiol homeostasis |
author_facet |
Pektaş Gökhan Pektaş Suzan Demir Öztekin Aynure Oztekin Coşkun Neşelioglu Salim Erel Özcan Sadi Gökhan |
author_sort |
Pektaş Gökhan |
title |
Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo |
title_short |
Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo |
title_full |
Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo |
title_fullStr |
Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo |
title_full_unstemmed |
Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo |
title_sort |
dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo |
publisher |
University of Belgrade, University of Novi Sad |
series |
Archives of Biological Sciences |
issn |
0354-4664 1821-4339 |
publishDate |
2019-01-01 |
description |
Vitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with generalized vitiligo and to determine its relationship with some of the demographical characteristics. Seventy-six generalized vitiligo patients and 67 healthy individuals were included in the study. Blood serum native thiol, disulfide and total thiol concentrations, together with some hematological parameters, were determined. Results demonstrated that native and total thiol contents, and their ratios, were significantly lower in vitiligo patients. Disulfide/native thiol and disulfide/total thiol ratios were significantly higher in the patient group. Progressivity of the disease strongly regulated the thiol/disulfide homeostasis in such a way that active vitiligo patients had reduced native and total thiol levels but increased disulfide/native thiol and disulfide/total thiol ratios. Moreover, there was a statistically significant negative correlation between both duration of the vitiligo and native and total thiol contents. As these results clearly demonstrated that thiol/disulfide homeostasis was shifted toward disulfide formation in patients with generalized vitiligo, determining the dynamic nature of thiol/disulfide homeostasis can be used to monitor disease progression. |
topic |
generalized vitiligo native thiol disulfide total thiol homeostasis |
url |
http://www.doiserbia.nb.rs/img/doi/0354-4664/2019/0354-46641800047P.pdf |
work_keys_str_mv |
AT pektasgokhan dynamicthioldisulfidehomeostasisinserumofpatientswithgeneralizedvitiligo AT pektassuzandemir dynamicthioldisulfidehomeostasisinserumofpatientswithgeneralizedvitiligo AT oztekinaynure dynamicthioldisulfidehomeostasisinserumofpatientswithgeneralizedvitiligo AT oztekincoskun dynamicthioldisulfidehomeostasisinserumofpatientswithgeneralizedvitiligo AT neselioglusalim dynamicthioldisulfidehomeostasisinserumofpatientswithgeneralizedvitiligo AT erelozcan dynamicthioldisulfidehomeostasisinserumofpatientswithgeneralizedvitiligo AT sadigokhan dynamicthioldisulfidehomeostasisinserumofpatientswithgeneralizedvitiligo |
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