Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription...

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Main Authors:	Michael Peitz, Tamara Bechler, Catrin Cornelia Thiele, Monika Veltel, Melanie Bloschies, Klaus Fliessbach, Alfredo Ramirez, Oliver Brüstle
Format:	Article
Language:	English
Published:	Elsevier 2018-05-01
Series:	Stem Cell Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506118301120

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spelling	doaj-201ec405aead41f19cd08592a0ddbd032020-11-25T00:26:47ZengElsevierStem Cell Research1873-50612018-05-0129250253Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotypeMichael Peitz0Tamara Bechler1Catrin Cornelia Thiele2Monika Veltel3Melanie Bloschies4Klaus Fliessbach5Alfredo Ramirez6Oliver Brüstle7Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty, Bonn 53127, Germany,; DZNE German Center for Neurodegenerative Diseases (DZNE), Bonn 53175, Germany,Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty, Bonn 53127, Germany,Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty, Bonn 53127, Germany,; DZNE German Center for Neurodegenerative Diseases (DZNE), Bonn 53175, Germany,Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty, Bonn 53127, Germany,Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty, Bonn 53127, Germany,DZNE German Center for Neurodegenerative Diseases (DZNE), Bonn 53175, Germany,; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany,Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany,; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany,; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty, Bonn 53127, Germany,; Corresponding author.Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.http://www.sciencedirect.com/science/article/pii/S1873506118301120
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michael Peitz Tamara Bechler Catrin Cornelia Thiele Monika Veltel Melanie Bloschies Klaus Fliessbach Alfredo Ramirez Oliver Brüstle
spellingShingle	Michael Peitz Tamara Bechler Catrin Cornelia Thiele Monika Veltel Melanie Bloschies Klaus Fliessbach Alfredo Ramirez Oliver Brüstle Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype Stem Cell Research
author_facet	Michael Peitz Tamara Bechler Catrin Cornelia Thiele Monika Veltel Melanie Bloschies Klaus Fliessbach Alfredo Ramirez Oliver Brüstle
author_sort	Michael Peitz
title	Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype
title_short	Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype
title_full	Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype
title_fullStr	Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype
title_full_unstemmed	Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype
title_sort	blood-derived integration-free ips cell line ukbi011-a from a diagnosed male alzheimer's disease patient with apoe ɛ4/ɛ4 genotype
publisher	Elsevier
series	Stem Cell Research
issn	1873-5061
publishDate	2018-05-01
description	Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
url	http://www.sciencedirect.com/science/article/pii/S1873506118301120
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Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

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