Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy
Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin ca...
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2008-01-01
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Online Access: | http://dx.doi.org/10.1155/2008/230307 |
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doaj-2021c46b86f34dd88c6f69c7abd05f5f2020-11-24T22:34:17ZengHindawi LimitedDisease Markers0278-02401875-86302008-01-0125632333710.1155/2008/230307Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman SpectroscopyMatthew D. Keller0Elizabeth M. Kanter1Chad A. Lieber2Shovan K. Majumder3Joanne Hutchings4Darrel L. Ellis5Richard B. Beaven6Nicholas Stone7Anita Mahadevan-Jansen8Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USACHOC Research Institute, Children’s Hospital of Orange County, Orange, CA, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USABiophotonics Research Group and Department of Pathology, Gloucestershire Royal Hospital, Gloucester, Gloucestershire, UKDivision of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USATri-State Women’s Health, Florence, KY, USABiophotonics Research Group and Department of Pathology, Gloucestershire Royal Hospital, Gloucester, Gloucestershire, UKDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USAEpithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined through four separate but related studies. Results from a clinical cervix study show that previous disease has a significant effect on the Raman signatures of the cervix, which allow for near 100% classification for discriminating previous disease versus a true normal. A Raman microspectroscopy study showed that Raman can detect changes due to adjacent regions of dysplasia or HPV that cannot be detected histologically, while a clinical skin study showed that Raman spectra may be detecting malignancy associated changes in tissues surrounding nonmelanoma skin cancers. Finally, results of an organotypic raft culture study provided support for both the skin and the in vitro cervix results. These studies add to the growing body of evidence that optical spectroscopy, in this case Raman spectral markers, can be used to detect subtle temporal and spatial effects in tissue near cancerous sites that go otherwise undetected by conventional histology.http://dx.doi.org/10.1155/2008/230307 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthew D. Keller Elizabeth M. Kanter Chad A. Lieber Shovan K. Majumder Joanne Hutchings Darrel L. Ellis Richard B. Beaven Nicholas Stone Anita Mahadevan-Jansen |
spellingShingle |
Matthew D. Keller Elizabeth M. Kanter Chad A. Lieber Shovan K. Majumder Joanne Hutchings Darrel L. Ellis Richard B. Beaven Nicholas Stone Anita Mahadevan-Jansen Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy Disease Markers |
author_facet |
Matthew D. Keller Elizabeth M. Kanter Chad A. Lieber Shovan K. Majumder Joanne Hutchings Darrel L. Ellis Richard B. Beaven Nicholas Stone Anita Mahadevan-Jansen |
author_sort |
Matthew D. Keller |
title |
Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy |
title_short |
Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy |
title_full |
Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy |
title_fullStr |
Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy |
title_full_unstemmed |
Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy |
title_sort |
detecting temporal and spatial effects of epithelial cancers with raman spectroscopy |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2008-01-01 |
description |
Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined through four separate but related studies. Results from a clinical cervix study show that previous disease has a significant effect on the Raman signatures of the cervix, which allow for near 100% classification for discriminating previous disease versus a true normal. A Raman microspectroscopy study showed that Raman can detect changes due to adjacent regions of dysplasia or HPV that cannot be detected histologically, while a clinical skin study showed that Raman spectra may be detecting malignancy associated changes in tissues surrounding nonmelanoma skin cancers. Finally, results of an organotypic raft culture study provided support for both the skin and the in vitro cervix results. These studies add to the growing body of evidence that optical spectroscopy, in this case Raman spectral markers, can be used to detect subtle temporal and spatial effects in tissue near cancerous sites that go otherwise undetected by conventional histology. |
url |
http://dx.doi.org/10.1155/2008/230307 |
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