Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy
Abstract Background This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). Methods Two hundred and thirty patients with non-metastatic NPC were analyzed in terms of freedom...
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doaj-20323bbba2a94262ab4760fd6a7ad09a2020-11-25T02:04:11ZengBMCRadiation Oncology1748-717X2019-04-011411810.1186/s13014-019-1261-9Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapyChih-Jen Huang0Ming-Yii Huang1Ming-Chen Paul Shih2Kai-yuan Cheng3Ka-Wo Lee4Tzu-Ying Lu5Shyng-Shiou Yuan6Pen-Tzu Fang7Department of Radiation Oncology, Kaohsiung Medical University HospitalDepartment of Radiation Oncology, Kaohsiung Medical University HospitalDepartment of Medical imaging, Kaohsiung Medical University HospitalDepartment of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University HospitalDepartment of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University HospitalDepartment of Radiation Oncology, Kaohsiung Medical University HospitalTranslational Research Center, Department of Obstetrics and Gynecology, Kaohsiung Medical University HospitalDepartment of Radiation Oncology, Kaohsiung Medical University HospitalAbstract Background This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). Methods Two hundred and thirty patients with non-metastatic NPC were analyzed in terms of freedom from local failure (FFLF), freedom from distant failure (FFDF), overall survival (OS), and disease-free survival (DFS). For each patient, the status of the sinus mucosa was flexibly assessed by documenting mucosal changes as indicated by differences between images obtained before radiotherapy and more than 6 months post-radiation. Results With a median follow-up of 39.7 months (8 to 81 months), 19 (8.26%) patients relapsed locally, 13 (5.65%) patients failed in the neck, and 26 (11.3%) patients developed distant metastases. The presence of sinusitis noted in images post-radiation was a significant predictor for DFS (p = 0.001), FFLF (p = 0.004), and FFDF (p = 0.015), in addition to having high negative predictive value for local relapse (97.5%). Conclusions This is the first study to investigate the prognostic value of post-radiation sinusitis in NPC patients treated with IMRT. Post-radiation sinusitis was found to be a significant predictor for DFS, FFLF, and FFDF, and was also found to have high negative predictive value for local recurrence (97.5%). It may thus be used as an additional tool for clinicians to determine the possibility of recurrence.http://link.springer.com/article/10.1186/s13014-019-1261-9Nasopharyngeal carcinomaIntensity-modulated radiation therapyPost-radiation sinusitisRecurrence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chih-Jen Huang Ming-Yii Huang Ming-Chen Paul Shih Kai-yuan Cheng Ka-Wo Lee Tzu-Ying Lu Shyng-Shiou Yuan Pen-Tzu Fang |
spellingShingle |
Chih-Jen Huang Ming-Yii Huang Ming-Chen Paul Shih Kai-yuan Cheng Ka-Wo Lee Tzu-Ying Lu Shyng-Shiou Yuan Pen-Tzu Fang Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy Radiation Oncology Nasopharyngeal carcinoma Intensity-modulated radiation therapy Post-radiation sinusitis Recurrence |
author_facet |
Chih-Jen Huang Ming-Yii Huang Ming-Chen Paul Shih Kai-yuan Cheng Ka-Wo Lee Tzu-Ying Lu Shyng-Shiou Yuan Pen-Tzu Fang |
author_sort |
Chih-Jen Huang |
title |
Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy |
title_short |
Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy |
title_full |
Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy |
title_fullStr |
Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy |
title_full_unstemmed |
Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy |
title_sort |
post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy |
publisher |
BMC |
series |
Radiation Oncology |
issn |
1748-717X |
publishDate |
2019-04-01 |
description |
Abstract Background This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). Methods Two hundred and thirty patients with non-metastatic NPC were analyzed in terms of freedom from local failure (FFLF), freedom from distant failure (FFDF), overall survival (OS), and disease-free survival (DFS). For each patient, the status of the sinus mucosa was flexibly assessed by documenting mucosal changes as indicated by differences between images obtained before radiotherapy and more than 6 months post-radiation. Results With a median follow-up of 39.7 months (8 to 81 months), 19 (8.26%) patients relapsed locally, 13 (5.65%) patients failed in the neck, and 26 (11.3%) patients developed distant metastases. The presence of sinusitis noted in images post-radiation was a significant predictor for DFS (p = 0.001), FFLF (p = 0.004), and FFDF (p = 0.015), in addition to having high negative predictive value for local relapse (97.5%). Conclusions This is the first study to investigate the prognostic value of post-radiation sinusitis in NPC patients treated with IMRT. Post-radiation sinusitis was found to be a significant predictor for DFS, FFLF, and FFDF, and was also found to have high negative predictive value for local recurrence (97.5%). It may thus be used as an additional tool for clinicians to determine the possibility of recurrence. |
topic |
Nasopharyngeal carcinoma Intensity-modulated radiation therapy Post-radiation sinusitis Recurrence |
url |
http://link.springer.com/article/10.1186/s13014-019-1261-9 |
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