Transcriptomic profiling of trichloroethylene exposure in male mouse liver

Transcriptomic profiling of trichloroethylene exposure in male mouse liver

Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation chang...

Full description

Bibliographic Details
Main Authors: Yan Jiang, Jiahong Chen, Jian Tong, Tao Chen
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Genomics Data
Subjects:
Trichloroethylene
mRNA
Liver
Tumor
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596015000045
id doaj-203fafa82b5549fa80245aa636536db4
record_format Article
spelling doaj-203fafa82b5549fa80245aa636536db42020-11-25T02:56:01ZengElsevierGenomics Data2213-59602015-03-013C14014210.1016/j.gdata.2015.01.002Transcriptomic profiling of trichloroethylene exposure in male mouse liverYan Jiang0Jiahong Chen1Jian Tong2Tao Chen3Department of Physiology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, ChinaDepartment of Toxicology, School of Public Health, Soochow University, Suzhou, ChinaDepartment of Toxicology, School of Public Health, Soochow University, Suzhou, ChinaDepartment of Toxicology, School of Public Health, Soochow University, Suzhou, ChinaChronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the experimental methods, quality controls, and other information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE58819. Our data provide useful information for gene expression responses to TCE in mouse liver.http://www.sciencedirect.com/science/article/pii/S2213596015000045TrichloroethylenemRNALiverTumorMouse
collection DOAJ
language English
format Article
sources DOAJ
author Yan Jiang
Jiahong Chen
Jian Tong
Tao Chen
spellingShingle Yan Jiang
Jiahong Chen
Jian Tong
Tao Chen
Transcriptomic profiling of trichloroethylene exposure in male mouse liver
Genomics Data
Trichloroethylene
mRNA
Liver
Tumor
Mouse
author_facet Yan Jiang
Jiahong Chen
Jian Tong
Tao Chen
author_sort Yan Jiang
title Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_short Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_full Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_fullStr Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_full_unstemmed Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_sort transcriptomic profiling of trichloroethylene exposure in male mouse liver
publisher Elsevier
series Genomics Data
issn 2213-5960
publishDate 2015-03-01
description Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the experimental methods, quality controls, and other information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE58819. Our data provide useful information for gene expression responses to TCE in mouse liver.
topic Trichloroethylene
mRNA
Liver
Tumor
Mouse
url http://www.sciencedirect.com/science/article/pii/S2213596015000045
work_keys_str_mv AT yanjiang transcriptomicprofilingoftrichloroethyleneexposureinmalemouseliver
AT jiahongchen transcriptomicprofilingoftrichloroethyleneexposureinmalemouseliver
AT jiantong transcriptomicprofilingoftrichloroethyleneexposureinmalemouseliver
AT taochen transcriptomicprofilingoftrichloroethyleneexposureinmalemouseliver
_version_ 1724714645290221568

Similar Items