The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years
Abstract Background Despite no international consensus on the diagnostic criteria for sarcopenia, low lean mass, muscle strength, and physical function are important risk factors for disability, frailty, and mortality in older individuals, as well as in a wide range of patients with muscle loss. Her...
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Format: | Article |
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Wiley
2019-12-01
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Series: | Journal of Cachexia, Sarcopenia and Muscle |
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Online Access: | https://doi.org/10.1002/jcsm.12477 |
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doaj-203fb5b4aa4546e3880c1557053e3e44 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Charlotte Suetta Bryan Haddock Julian Alcazar Tim Noerst Ole M. Hansen Helle Ludvig Rikke Stefan Kamper Peter Schnohr Eva Prescott Lars L. Andersen Ulrik Frandsen Per Aagaard Jens Bülow Peter Hovind Lene Simonsen |
spellingShingle |
Charlotte Suetta Bryan Haddock Julian Alcazar Tim Noerst Ole M. Hansen Helle Ludvig Rikke Stefan Kamper Peter Schnohr Eva Prescott Lars L. Andersen Ulrik Frandsen Per Aagaard Jens Bülow Peter Hovind Lene Simonsen The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years Journal of Cachexia, Sarcopenia and Muscle Sarcopenia Body composition DXA Lean mass Handgrip strength Leg power |
author_facet |
Charlotte Suetta Bryan Haddock Julian Alcazar Tim Noerst Ole M. Hansen Helle Ludvig Rikke Stefan Kamper Peter Schnohr Eva Prescott Lars L. Andersen Ulrik Frandsen Per Aagaard Jens Bülow Peter Hovind Lene Simonsen |
author_sort |
Charlotte Suetta |
title |
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years |
title_short |
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years |
title_full |
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years |
title_fullStr |
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years |
title_full_unstemmed |
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years |
title_sort |
copenhagen sarcopenia study: lean mass, strength, power, and physical function in a danish cohort aged 20–93 years |
publisher |
Wiley |
series |
Journal of Cachexia, Sarcopenia and Muscle |
issn |
2190-5991 2190-6009 |
publishDate |
2019-12-01 |
description |
Abstract Background Despite no international consensus on the diagnostic criteria for sarcopenia, low lean mass, muscle strength, and physical function are important risk factors for disability, frailty, and mortality in older individuals, as well as in a wide range of patients with muscle loss. Here, we provide a population‐based reference material of total and regional lean body mass, muscle strength/power parameters, and physical function in a healthy cohort of Danish men and women across the lifespan. Methods Volunteers aged 20–93 years from the Copenhagen City Heart Study were invited to establish a Danish reference material (Copenhagen Sarcopenia Study) on lean mass characteristics [appendicular lean mass (ALM), iDXA, GE Lunar], muscle function [handgrip strength (HGS), Jamar dynamometer and leg extension power (LEP), Nottingham Power Rig], and physical function [30 s sit‐to‐stand test (STS), 10‐m maximal and habitual gait speed (GS)]. Results A total of 1305 participants [729 women (age: 56.4 ± 18.9 years, height: 1.66 ± 0.01 m, body mass index: 24.6 ± 4.3 kg/m2 and 576 men, age: 57.0 ± 17.5 years, height: 1.80 ± 0.07 m, body mass index: 26.0 ± 3.9 kg/m2] completed all measurements and were included in the present analysis. Lean mass characteristics (TLM, ALM, and ALM/h2) decreased with increasing age in both men and women (P < 0.001). Men demonstrated larger absolute and relative total ALM and higher HGS and LEP compared with women at all age intervals (P < 0.001). HGS and LEP decreased progressively with age in both men and women (P < 0.01); 30 s STS performance, habitual GS, and maximal GS decreased at an accellerated rate of decline with increasing age in both men and women (P < 0.001). Habitual GS was reduced in men and women aged ≥70 years, while maximal GS was reduced from the age of ≥60 years compared with young adults (P < 0.001). Regardless of sex, 30 s STS was reduced from the age of ≥50 years compared with the young reference group (P < 0.001) Conclusions While the power‐based measurements (LEP and 30 s STS) started to decline already at age +50 years, less power‐based parameters (GS and HGS) and lean mass characteristics (TLM, ALM, and ALM/h2) remained unaltered until after the age of +70 years. Notably, the cut‐off thresholds derived in the present study differed from earlier reference data, which underlines the importance of obtaining updated and local reference materials. |
topic |
Sarcopenia Body composition DXA Lean mass Handgrip strength Leg power |
url |
https://doi.org/10.1002/jcsm.12477 |
work_keys_str_mv |
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doaj-203fb5b4aa4546e3880c1557053e3e442020-11-25T03:02:43ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092019-12-011061316132910.1002/jcsm.12477The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 yearsCharlotte Suetta0Bryan Haddock1Julian Alcazar2Tim Noerst3Ole M. Hansen4Helle Ludvig5Rikke Stefan Kamper6Peter Schnohr7Eva Prescott8Lars L. Andersen9Ulrik Frandsen10Per Aagaard11Jens Bülow12Peter Hovind13Lene Simonsen14Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet‐Glostrup Copenhagen University Hospital Copenhagen DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet‐Glostrup Copenhagen University Hospital Copenhagen DenmarkGeriatric Research Unit, Geriatric Department Bispebjerg‐Frederiksberg University Hospital Copenhagen DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet‐Glostrup Copenhagen University Hospital Copenhagen DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet‐Glostrup Copenhagen University Hospital Copenhagen DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet‐Glostrup Copenhagen University Hospital Copenhagen DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet‐Glostrup Copenhagen University Hospital Copenhagen DenmarkCopenhagen City Heart Study Bispebjerg‐Frederiksberg University Hospital Copenhagen DenmarkCopenhagen City Heart Study Bispebjerg‐Frederiksberg University Hospital Copenhagen DenmarkNational Research Centre for the Working Environment Copenhagen DenmarkDepartment of Sports Science and Clinical Biomechanics, Research Unit for Muscle Physiology and Biomechanics University of Southern Denmark Odense DenmarkDepartment of Sports Science and Clinical Biomechanics, Research Unit for Muscle Physiology and Biomechanics University of Southern Denmark Odense DenmarkDepartment of Clinical Physiology and Nuclear Medicine Bispebjerg‐Frederiksberg University Hospital Copenhagen DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet‐Glostrup Copenhagen University Hospital Copenhagen DenmarkDepartment of Clinical Physiology and Nuclear Medicine Bispebjerg‐Frederiksberg University Hospital Copenhagen DenmarkAbstract Background Despite no international consensus on the diagnostic criteria for sarcopenia, low lean mass, muscle strength, and physical function are important risk factors for disability, frailty, and mortality in older individuals, as well as in a wide range of patients with muscle loss. Here, we provide a population‐based reference material of total and regional lean body mass, muscle strength/power parameters, and physical function in a healthy cohort of Danish men and women across the lifespan. Methods Volunteers aged 20–93 years from the Copenhagen City Heart Study were invited to establish a Danish reference material (Copenhagen Sarcopenia Study) on lean mass characteristics [appendicular lean mass (ALM), iDXA, GE Lunar], muscle function [handgrip strength (HGS), Jamar dynamometer and leg extension power (LEP), Nottingham Power Rig], and physical function [30 s sit‐to‐stand test (STS), 10‐m maximal and habitual gait speed (GS)]. Results A total of 1305 participants [729 women (age: 56.4 ± 18.9 years, height: 1.66 ± 0.01 m, body mass index: 24.6 ± 4.3 kg/m2 and 576 men, age: 57.0 ± 17.5 years, height: 1.80 ± 0.07 m, body mass index: 26.0 ± 3.9 kg/m2] completed all measurements and were included in the present analysis. Lean mass characteristics (TLM, ALM, and ALM/h2) decreased with increasing age in both men and women (P < 0.001). Men demonstrated larger absolute and relative total ALM and higher HGS and LEP compared with women at all age intervals (P < 0.001). HGS and LEP decreased progressively with age in both men and women (P < 0.01); 30 s STS performance, habitual GS, and maximal GS decreased at an accellerated rate of decline with increasing age in both men and women (P < 0.001). Habitual GS was reduced in men and women aged ≥70 years, while maximal GS was reduced from the age of ≥60 years compared with young adults (P < 0.001). Regardless of sex, 30 s STS was reduced from the age of ≥50 years compared with the young reference group (P < 0.001) Conclusions While the power‐based measurements (LEP and 30 s STS) started to decline already at age +50 years, less power‐based parameters (GS and HGS) and lean mass characteristics (TLM, ALM, and ALM/h2) remained unaltered until after the age of +70 years. Notably, the cut‐off thresholds derived in the present study differed from earlier reference data, which underlines the importance of obtaining updated and local reference materials.https://doi.org/10.1002/jcsm.12477SarcopeniaBody compositionDXALean massHandgrip strengthLeg power |