Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax
Abstract A 77‐year‐old man who had a persistent productive cough for one month was admitted to our hospital. Chest computed tomography (CT) revealed subpleural nodular opacities, irregular pleural thickening with bilateral basal predominance, and a small right pleural effusion. Aspirated fluid was e...
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doaj-2044d1cdade848ab9adbbf42bbe2adf82020-11-25T03:41:03ZengWileyThoracic Cancer1759-77061759-77142020-11-0111113407340810.1111/1759-7714.13665Unusual lung involvements of invasive mucinous adenocarcinoma with chylothoraxAyako Aoki0Yu Hara1Koji Okudela2Yoshihiro Ishikawa3Kosei Doshita4Hisashi Hashimoto5Kentaro Nakashima6Nobuyuki Horita7Nobuaki Kobayashi8Takeshi Kaneko9Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Pathology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Thoracic Surgery Yokohama City University Hospital Yokohama JapanDepartment of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Pulmonology Yokohama City University Graduate School of Medicine Yokohama JapanAbstract A 77‐year‐old man who had a persistent productive cough for one month was admitted to our hospital. Chest computed tomography (CT) revealed subpleural nodular opacities, irregular pleural thickening with bilateral basal predominance, and a small right pleural effusion. Aspirated fluid was exudative and had the appearance of chylothorax without malignant cells. Surgical lung biopsy specimen showed focal proliferation of neoplastic epithelial cells with lepidic‐predominant pattern and abundant mucus in the alveolar spaces, consistent with invasive mucinous adenocarcinoma (IMA). The results of PD‐L1 expression and the EGFR, ALK, ROS1, and BRAF mutation status analyzed by next generation sequencer were all negative. IMA should be considered in the differential diagnosis of subpleural micronodular opacities accompanied by pleural effusion (chylothorax) on chest CT. Key points Significant findings of the study This case showed subpleural micronodular opacities and chylothorax as unusual chest computed tomography (CT) patterns for invasive mucinous adenocarcinoma (IMA). What this study adds Invasive mucinous adenocarcinoma (IMA) should be considered in the differential diagnosis of subpleural micronodular opacities accompanied by pleural effusion on chest CT.https://doi.org/10.1111/1759-7714.13665Chylothoraxcomputed tomographyinvasive mucinous adenocarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ayako Aoki Yu Hara Koji Okudela Yoshihiro Ishikawa Kosei Doshita Hisashi Hashimoto Kentaro Nakashima Nobuyuki Horita Nobuaki Kobayashi Takeshi Kaneko |
spellingShingle |
Ayako Aoki Yu Hara Koji Okudela Yoshihiro Ishikawa Kosei Doshita Hisashi Hashimoto Kentaro Nakashima Nobuyuki Horita Nobuaki Kobayashi Takeshi Kaneko Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax Thoracic Cancer Chylothorax computed tomography invasive mucinous adenocarcinoma |
author_facet |
Ayako Aoki Yu Hara Koji Okudela Yoshihiro Ishikawa Kosei Doshita Hisashi Hashimoto Kentaro Nakashima Nobuyuki Horita Nobuaki Kobayashi Takeshi Kaneko |
author_sort |
Ayako Aoki |
title |
Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax |
title_short |
Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax |
title_full |
Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax |
title_fullStr |
Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax |
title_full_unstemmed |
Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax |
title_sort |
unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax |
publisher |
Wiley |
series |
Thoracic Cancer |
issn |
1759-7706 1759-7714 |
publishDate |
2020-11-01 |
description |
Abstract A 77‐year‐old man who had a persistent productive cough for one month was admitted to our hospital. Chest computed tomography (CT) revealed subpleural nodular opacities, irregular pleural thickening with bilateral basal predominance, and a small right pleural effusion. Aspirated fluid was exudative and had the appearance of chylothorax without malignant cells. Surgical lung biopsy specimen showed focal proliferation of neoplastic epithelial cells with lepidic‐predominant pattern and abundant mucus in the alveolar spaces, consistent with invasive mucinous adenocarcinoma (IMA). The results of PD‐L1 expression and the EGFR, ALK, ROS1, and BRAF mutation status analyzed by next generation sequencer were all negative. IMA should be considered in the differential diagnosis of subpleural micronodular opacities accompanied by pleural effusion (chylothorax) on chest CT. Key points Significant findings of the study This case showed subpleural micronodular opacities and chylothorax as unusual chest computed tomography (CT) patterns for invasive mucinous adenocarcinoma (IMA). What this study adds Invasive mucinous adenocarcinoma (IMA) should be considered in the differential diagnosis of subpleural micronodular opacities accompanied by pleural effusion on chest CT. |
topic |
Chylothorax computed tomography invasive mucinous adenocarcinoma |
url |
https://doi.org/10.1111/1759-7714.13665 |
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