METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)

METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)

The article presents an overview of the main methods for producing liposomal medications, such as convectional and acoustic methods, high pressure method, detergent dissolution and removal method and the vapor method with phase inversion. The problems of hydrophobic technology of antioxidant pharmac...

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Main Authors: A. A. Novikova, P. Kezimana, Ya. M. Stanishevskiy
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
Series:Разработка и регистрация лекарственных средств
Subjects:
liposomes
phospholipids
directional transport
thin film hydration method
sonication
Online Access:https://www.pharmjournal.ru/jour/article/view/419
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spelling doaj-204a122d1101425f8be49663e811e4ce2021-07-28T13:06:55ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102134138419METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)A. A. Novikova0P. Kezimana1Ya. M. Stanishevskiy2Peoples' Friendship University of Russia (RUDN University) (Institute of Biochemical Technology and Nanotechnology)Peoples' Friendship University of Russia (RUDN University) (Institute of Biochemical Technology and Nanotechnology)Peoples' Friendship University of Russia (RUDN University) (Institute of Biochemical Technology and Nanotechnology)The article presents an overview of the main methods for producing liposomal medications, such as convectional and acoustic methods, high pressure method, detergent dissolution and removal method and the vapor method with phase inversion. The problems of hydrophobic technology of antioxidant pharmaceuticals (low solubility and chemical stability of such drug) and the advantages of liposomes to deliver them are reported. It is established that the most promising technology of producing liposomes containing drugs with antioxidant effects is a thin film hydration method with further sonication.https://www.pharmjournal.ru/jour/article/view/419liposomesphospholipidsdirectional transportthin film hydration methodsonication
collection DOAJ
language Russian
format Article
sources DOAJ
author A. A. Novikova
P. Kezimana
Ya. M. Stanishevskiy
spellingShingle A. A. Novikova
P. Kezimana
Ya. M. Stanishevskiy
METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
Разработка и регистрация лекарственных средств
liposomes
phospholipids
directional transport
thin film hydration method
sonication
author_facet A. A. Novikova
P. Kezimana
Ya. M. Stanishevskiy
author_sort A. A. Novikova
title METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
title_short METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
title_full METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
title_fullStr METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
title_full_unstemmed METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
title_sort methods of obtaining liposomes, used as drug delivery systems (review)
publisher LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
series Разработка и регистрация лекарственных средств
issn 2305-2066
2658-5049
publishDate 2019-01-01
description The article presents an overview of the main methods for producing liposomal medications, such as convectional and acoustic methods, high pressure method, detergent dissolution and removal method and the vapor method with phase inversion. The problems of hydrophobic technology of antioxidant pharmaceuticals (low solubility and chemical stability of such drug) and the advantages of liposomes to deliver them are reported. It is established that the most promising technology of producing liposomes containing drugs with antioxidant effects is a thin film hydration method with further sonication.
topic liposomes
phospholipids
directional transport
thin film hydration method
sonication
url https://www.pharmjournal.ru/jour/article/view/419
work_keys_str_mv AT aanovikova methodsofobtainingliposomesusedasdrugdeliverysystemsreview
AT pkezimana methodsofobtainingliposomesusedasdrugdeliverysystemsreview
AT yamstanishevskiy methodsofobtainingliposomesusedasdrugdeliverysystemsreview
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