LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS
Human growth and development, starting from conception, are characterized by a progressive increase in body and organ dimensions, as well as specific functional maturity, under the influence of genetic as well as environmental and epigenetic determinants. Beyond a possible normal familial trait, inc...
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Online Access: | http://www.embj.org/wp-content/uploads/2020/07/Piro_29.pdf |
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doaj-205769e5b20f4920bd0e04e59cef15d12020-11-25T03:52:32ZengAssociazione Italiana Giovani MediciEuromediterranean Biomedical Journal2279-71652279-71652020-07-01152911612010.3269/1970-5492.2020.15.29LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTSEttore Piro0https://orcid.org/0000-0003-4727-1628University of PalermoHuman growth and development, starting from conception, are characterized by a progressive increase in body and organ dimensions, as well as specific functional maturity, under the influence of genetic as well as environmental and epigenetic determinants. Beyond a possible normal familial trait, increased fetal growth resulting in a large for gestational age newborn, isolated macrosomia or that associated with congenital malformation, can be attributable to both maternal metabolic and genetic pathology. Overgrowth syndromes are a heterogeneous group of diseases characterized by excessive tissue development often concomitant to neurodevelopmental involvement. Recently, an increased risk of fetal overgrowth with Assisted Reproductive Technology has been reported. Thus, in pediatric practice, it is fundamental to monitor any patient who presents with increased growth parameters, variable malformations, neurodevelopmental delay, and distinctive features from birth, aiming to ensure as adequate a medical management as possible, and for some of the disorders, strict tumor monitoring is also necessary. http://www.embj.org/wp-content/uploads/2020/07/Piro_29.pdfdiabetic motherdevelopmental delaylarge for gestational agearttumor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ettore Piro |
spellingShingle |
Ettore Piro LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS Euromediterranean Biomedical Journal diabetic mother developmental delay large for gestational age art tumor |
author_facet |
Ettore Piro |
author_sort |
Ettore Piro |
title |
LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS |
title_short |
LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS |
title_full |
LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS |
title_fullStr |
LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS |
title_full_unstemmed |
LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS |
title_sort |
large for gestational age, macrosomia, overgrowth: an update on definitions and determinants |
publisher |
Associazione Italiana Giovani Medici |
series |
Euromediterranean Biomedical Journal |
issn |
2279-7165 2279-7165 |
publishDate |
2020-07-01 |
description |
Human growth and development, starting from conception, are characterized by a progressive increase in body and organ dimensions, as well as specific functional maturity, under the influence of genetic as well as environmental and epigenetic determinants. Beyond a possible normal familial trait, increased fetal growth resulting in a large for gestational age newborn, isolated macrosomia or that associated with congenital malformation, can be attributable to both maternal metabolic and genetic pathology. Overgrowth syndromes are a heterogeneous group of diseases characterized by excessive tissue development often concomitant to neurodevelopmental involvement. Recently, an increased risk of fetal overgrowth with Assisted Reproductive Technology has been reported. Thus, in pediatric practice, it is fundamental to monitor any patient who presents with increased growth parameters, variable malformations, neurodevelopmental delay, and distinctive features from birth, aiming to ensure as adequate a medical management as possible, and for some of the disorders, strict tumor monitoring is also necessary. |
topic |
diabetic mother developmental delay large for gestational age art tumor |
url |
http://www.embj.org/wp-content/uploads/2020/07/Piro_29.pdf |
work_keys_str_mv |
AT ettorepiro largeforgestationalagemacrosomiaovergrowthanupdateondefinitionsanddeterminants |
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1724482376006893568 |