The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis
The tumor necrosis factor-α (TNF-α) golimumab (GLM), that is a fully human monoclonal anti-body, was registered in Russia in 2012 to treat rheumatic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis. Its distinguishing characteristics are a high affinity fo...
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doaj-20582b9ee1724087a86cde39507b96732021-07-29T09:00:09ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2014-12-0184768510.14412/1996-7012-2014-4-76-851880The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritisNatalia Vladimirovna Chichasova0I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaThe tumor necrosis factor-α (TNF-α) golimumab (GLM), that is a fully human monoclonal anti-body, was registered in Russia in 2012 to treat rheumatic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis. Its distinguishing characteristics are a high affinity for TNF-α and easiness-to-use: the drug as a 0.5-ml solution is injected subcutaneously once monthly. The registration of the medication was followed by the implementation of a massive program of clinical trials. The randomized placebo-controlled GO-FORWARD, GO-BEFORE, and GO-AFTER studies have indicated that GLM is effective in patients with RA from different subgroups and has a favorable safety profile as compared to that of the entire class of biological agents. According to the data of these studies, GLM had a positive effect on the functional status and quality of life in patients with RA: there was a significantly greater decrease in HAQ scores in both the early and long open treatment phases (to 5 years) and in fatigability than in the control group (p=0.032), physical and mental health improvements, as shown by the SF-36 questionnaire, and a significant reduction in disability.https://mrj.ima-press.net/mrj/article/view/579rheumatoid arthritisdisease-modifying antirheumatic drugsbiological agentsgolimumab |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Natalia Vladimirovna Chichasova |
spellingShingle |
Natalia Vladimirovna Chichasova The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis Современная ревматология rheumatoid arthritis disease-modifying antirheumatic drugs biological agents golimumab |
author_facet |
Natalia Vladimirovna Chichasova |
author_sort |
Natalia Vladimirovna Chichasova |
title |
The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis |
title_short |
The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis |
title_full |
The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis |
title_fullStr |
The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis |
title_full_unstemmed |
The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis |
title_sort |
tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis |
publisher |
IMA-PRESS LLC |
series |
Современная ревматология |
issn |
1996-7012 2310-158X |
publishDate |
2014-12-01 |
description |
The tumor necrosis factor-α (TNF-α) golimumab (GLM), that is a fully human monoclonal anti-body, was registered in Russia in 2012 to treat rheumatic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis. Its distinguishing characteristics are a high affinity for TNF-α and easiness-to-use: the drug as a 0.5-ml solution is injected subcutaneously once monthly. The registration of the medication was followed by the implementation of a massive program of clinical trials. The randomized placebo-controlled GO-FORWARD, GO-BEFORE, and GO-AFTER studies have indicated that GLM is effective in patients with RA from different subgroups and has a favorable safety profile as compared to that of the entire class of biological agents. According to the data of these studies, GLM had a positive effect on the functional status and quality of life in patients with RA: there was a significantly greater decrease in HAQ scores in both the early and long open treatment phases (to 5 years) and in fatigability than in the control group (p=0.032), physical and mental health improvements, as shown by the SF-36 questionnaire, and a significant reduction in disability. |
topic |
rheumatoid arthritis disease-modifying antirheumatic drugs biological agents golimumab |
url |
https://mrj.ima-press.net/mrj/article/view/579 |
work_keys_str_mv |
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