Effect of analgesics, antidepressants and their combinations on changes of structures' of the central nervous system activity in animals with simulated depression

• Main Authors: Khomiak O.V., Opryshko V.I.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2012-01-01
• Series: Морфологія
• Subjects: analgesics; antidepressants; combination; neurophysiology; rabbits
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2012-06-02/12kovtmd.pdf

Experiments were carried out on outbred rabbits of both sexes using neurophysiological methods. We resurched the ability of analgesics, antidepressants and their combinations tochange parameters of electrophysiological brain activity under conditions of normal functioning of the central nervous system and on the background ofsimulated depression. Found that in brain pathology combination analgesics with amitriptyline caused activation of the reticular formation (RF) and in-creased excitability of dorsomedial tonsils (DMT) in comparison with its action in intact rabbits. Analysis of these data on reserpine showed the change of the sign of excitability in the frontal cortex (FC), RF (from inhibition to activation), and re-duction in the dorsal hippocampus (DH), or leveling DMT increased excitability of brain structures under the influence of this combination. Functional relationships between structures were characterized by increasing activating influence of RFon the FC and inhibiting influence of RFon DMT (increasing analgesic activity) and reduce brake control DH on FC (increase antidepressant properties). Notably, the combination of celecoxib with the amitriptyline caused fewer changes in excitability of brain structures and intracentral relationships between them that assotiates with less manifested analgesic activity com-pared with the combination of" meloxicam +amitriptyline."