Acetaminophen Use Concomitant with Long-Lasting Flucloxacillin Therapy: A Dangerous Combination

Acetaminophen Use Concomitant with Long-Lasting Flucloxacillin Therapy: A Dangerous Combination

Acetaminophen and flucloxacillin both interfere with the ?-glutamyl cycle. Long-lasting concomitant use of flucloxacillin and acetaminophen can lead to 5-oxoproline accumulation and severe high anion gap metabolic acidosis. Females and patients with sepsis, impaired kidney and/or liver function, mal...

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Bibliographic Details
Main Authors: Luuk René van den Bersselaar, Judith Maria Dimphena van den Brule, Johannes Gerardus van der Hoeven
Format: Article
Language:English
Published: SMC MEDIA SRL 2020-04-01
Series:European Journal of Case Reports in Internal Medicine
Subjects:
5-oxoproline
acetaminophen
flucloxacillin
anion gap
metabolic acidosis
Online Access:https://www.ejcrim.com/index.php/EJCRIM/article/view/1569

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