The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress...

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Main Authors:	Chang K. Zhao, Chan Li, Xian H. Wang, Yu J. Bao, Fu H. Yang, Mei Huang
Format:	Article
Language:	English
Published:	The Royal Society 2018-01-01
Series:	Royal Society Open Science
Subjects:	10-hydroxy camptothecin pro-drug regio-selective conjugate in vitro
Online Access:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.172317

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spelling	doaj-2064a4f5f32c4a71ab807af9a706b19d2020-11-25T03:36:55ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015610.1098/rsos.172317172317The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitroChang K. ZhaoChan LiXian H. WangYu J. BaoFu H. YangMei HuangA series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro. These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.17231710-hydroxy camptothecinpro-drugregio-selectiveconjugatein vitro
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chang K. Zhao Chan Li Xian H. Wang Yu J. Bao Fu H. Yang Mei Huang
spellingShingle	Chang K. Zhao Chan Li Xian H. Wang Yu J. Bao Fu H. Yang Mei Huang The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro Royal Society Open Science 10-hydroxy camptothecin pro-drug regio-selective conjugate in vitro
author_facet	Chang K. Zhao Chan Li Xian H. Wang Yu J. Bao Fu H. Yang Mei Huang
author_sort	Chang K. Zhao
title	The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_short	The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_full	The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_fullStr	The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_full_unstemmed	The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_sort	regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
publisher	The Royal Society
series	Royal Society Open Science
issn	2054-5703
publishDate	2018-01-01
description	A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro. These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.
topic	10-hydroxy camptothecin pro-drug regio-selective conjugate in vitro
url	https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.172317
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The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

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