Specialized areas for value updating and goal selection in the primate orbitofrontal cortex
The macaque orbitofrontal cortex (OFC) is essential for selecting goals based on current, updated values of expected reward outcomes. As monkeys consume a given type of reward to satiety, its value diminishes, and OFC damage impairs the ability to shift goal choices away from devalued outcomes. To e...
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doaj-206665986b204d84b6ca2007cc5649472021-05-05T00:10:26ZengeLife Sciences Publications LtdeLife2050-084X2015-12-01410.7554/eLife.11695Specialized areas for value updating and goal selection in the primate orbitofrontal cortexElisabeth A Murray0https://orcid.org/0000-0003-1450-1642Emily J Moylan1Kadharbatcha S Saleem2Benjamin M Basile3Janita Turchi4Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, United StatesSection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, United StatesSection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, United StatesSection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, United StatesSection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, United StatesThe macaque orbitofrontal cortex (OFC) is essential for selecting goals based on current, updated values of expected reward outcomes. As monkeys consume a given type of reward to satiety, its value diminishes, and OFC damage impairs the ability to shift goal choices away from devalued outcomes. To examine the contributions of OFC’s components to goal selection, we reversibly inactivated either its anterior (area 11) or posterior (area 13) parts. We found that neurons in area 13 must be active during the selective satiation procedure to enable the updating of outcome valuations. After this updating has occurred, however, area 13 is not needed to select goals based on this knowledge. In contrast, neurons in area 11 do not need to be active during the value-updating process. Instead, inactivation of this area during choices causes an impairment. These findings demonstrate selective and complementary specializations within the OFC.https://elifesciences.org/articles/11695macaque monkeydecision makingreinforcer devaluationgoal neglect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisabeth A Murray Emily J Moylan Kadharbatcha S Saleem Benjamin M Basile Janita Turchi |
spellingShingle |
Elisabeth A Murray Emily J Moylan Kadharbatcha S Saleem Benjamin M Basile Janita Turchi Specialized areas for value updating and goal selection in the primate orbitofrontal cortex eLife macaque monkey decision making reinforcer devaluation goal neglect |
author_facet |
Elisabeth A Murray Emily J Moylan Kadharbatcha S Saleem Benjamin M Basile Janita Turchi |
author_sort |
Elisabeth A Murray |
title |
Specialized areas for value updating and goal selection in the primate orbitofrontal cortex |
title_short |
Specialized areas for value updating and goal selection in the primate orbitofrontal cortex |
title_full |
Specialized areas for value updating and goal selection in the primate orbitofrontal cortex |
title_fullStr |
Specialized areas for value updating and goal selection in the primate orbitofrontal cortex |
title_full_unstemmed |
Specialized areas for value updating and goal selection in the primate orbitofrontal cortex |
title_sort |
specialized areas for value updating and goal selection in the primate orbitofrontal cortex |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2015-12-01 |
description |
The macaque orbitofrontal cortex (OFC) is essential for selecting goals based on current, updated values of expected reward outcomes. As monkeys consume a given type of reward to satiety, its value diminishes, and OFC damage impairs the ability to shift goal choices away from devalued outcomes. To examine the contributions of OFC’s components to goal selection, we reversibly inactivated either its anterior (area 11) or posterior (area 13) parts. We found that neurons in area 13 must be active during the selective satiation procedure to enable the updating of outcome valuations. After this updating has occurred, however, area 13 is not needed to select goals based on this knowledge. In contrast, neurons in area 11 do not need to be active during the value-updating process. Instead, inactivation of this area during choices causes an impairment. These findings demonstrate selective and complementary specializations within the OFC. |
topic |
macaque monkey decision making reinforcer devaluation goal neglect |
url |
https://elifesciences.org/articles/11695 |
work_keys_str_mv |
AT elisabethamurray specializedareasforvalueupdatingandgoalselectionintheprimateorbitofrontalcortex AT emilyjmoylan specializedareasforvalueupdatingandgoalselectionintheprimateorbitofrontalcortex AT kadharbatchassaleem specializedareasforvalueupdatingandgoalselectionintheprimateorbitofrontalcortex AT benjaminmbasile specializedareasforvalueupdatingandgoalselectionintheprimateorbitofrontalcortex AT janitaturchi specializedareasforvalueupdatingandgoalselectionintheprimateorbitofrontalcortex |
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1721476469481275392 |