A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells.
SALL4 is a member of the SALL gene family that encodes a group of putative developmental transcription factors. Murine Sall4 plays a critical role in maintaining embryonic stem cell (ES cell) pluripotency and self-renewal. We have shown that Sall4 activates Oct4 and is a master regulator in murine E...
Main Authors: | Jianchang Yang, Chong Gao, Li Chai, Yupo Ma |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-05-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2874005?pdf=render |
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