Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation
Abstract Background Bacterial respiratory infections (BRI) are major complications contributing to increased morbidity and mortality after lung transplantation (LT). This study analyzed epidemiology and outcome of 175 consecutive patients developing BRI in ICU after LT between 2006 and 2012. Methods...
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doaj-208a401135344d909d3467013f49338d2020-11-25T00:02:27ZengBMCBMC Pulmonary Medicine1471-24662018-03-011811910.1186/s12890-018-0605-9Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantationSebastien Tanaka0Claire Geneve1Gianpiero Tebano2Nathalie Grall3Pascal Piednoir4Régis Bronchard5Mathieu Godement6Enora Atchade7Pascal Augustin8Herve Mal9Yves Castier10Philippe Montravers11Mathieu Desmard12APHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationUniversité Denis Diderot, PRESS Sorbonne CitéAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationUniversité Denis Diderot, PRESS Sorbonne CitéUniversité Denis Diderot, PRESS Sorbonne CitéAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAPHP, CHU Bichat-Claude Bernard, Département d’Anesthésie RéanimationAbstract Background Bacterial respiratory infections (BRI) are major complications contributing to increased morbidity and mortality after lung transplantation (LT). This study analyzed epidemiology and outcome of 175 consecutive patients developing BRI in ICU after LT between 2006 and 2012. Methods Three situations were described: colonization determined in donors and recipients, pneumonia and tracheobronchitis during the first 28 postoperative days. Severity score, demographic, bacteriologic and outcome data were collected. Results 26% of donors and 31% of recipients were colonized. 92% of recipients developed BRI, including at least one episode of pneumonia in 19% of recipients. Only 21% of recipients developed BRI with an organism cultured from the donor’s samples, while 40% of recipients developed BRI with their own bacteria cultured before LT. Purulent sputum appears to be an important factor to discriminate tracheobronchitis from pneumonia. When compared to patients with tracheobronchitis, those with pneumonia had longer durations of mechanical ventilation (13 [3–27] vs 3 [29], p = 0.0005) and ICU stay (24 [16–34] vs 14 [9-22], p = 0.002). Pneumonia was associated with higher 28-day (11 (32%) vs 9 (7%), p = 0.0004) and one-year mortality rates (21 (61%) vs 24 (19%), p ≤ 0.0001). Conclusions These data confirm the high frequency of BRI right from the early postoperative period and the poor prognosis of pneumonia after LT.http://link.springer.com/article/10.1186/s12890-018-0605-9Lung transplantationPneumoniaBronchitisMortalityICU |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sebastien Tanaka Claire Geneve Gianpiero Tebano Nathalie Grall Pascal Piednoir Régis Bronchard Mathieu Godement Enora Atchade Pascal Augustin Herve Mal Yves Castier Philippe Montravers Mathieu Desmard |
spellingShingle |
Sebastien Tanaka Claire Geneve Gianpiero Tebano Nathalie Grall Pascal Piednoir Régis Bronchard Mathieu Godement Enora Atchade Pascal Augustin Herve Mal Yves Castier Philippe Montravers Mathieu Desmard Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation BMC Pulmonary Medicine Lung transplantation Pneumonia Bronchitis Mortality ICU |
author_facet |
Sebastien Tanaka Claire Geneve Gianpiero Tebano Nathalie Grall Pascal Piednoir Régis Bronchard Mathieu Godement Enora Atchade Pascal Augustin Herve Mal Yves Castier Philippe Montravers Mathieu Desmard |
author_sort |
Sebastien Tanaka |
title |
Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation |
title_short |
Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation |
title_full |
Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation |
title_fullStr |
Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation |
title_full_unstemmed |
Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation |
title_sort |
morbidity and mortality related to pneumonia and tracheobronchitis in icu after lung transplantation |
publisher |
BMC |
series |
BMC Pulmonary Medicine |
issn |
1471-2466 |
publishDate |
2018-03-01 |
description |
Abstract Background Bacterial respiratory infections (BRI) are major complications contributing to increased morbidity and mortality after lung transplantation (LT). This study analyzed epidemiology and outcome of 175 consecutive patients developing BRI in ICU after LT between 2006 and 2012. Methods Three situations were described: colonization determined in donors and recipients, pneumonia and tracheobronchitis during the first 28 postoperative days. Severity score, demographic, bacteriologic and outcome data were collected. Results 26% of donors and 31% of recipients were colonized. 92% of recipients developed BRI, including at least one episode of pneumonia in 19% of recipients. Only 21% of recipients developed BRI with an organism cultured from the donor’s samples, while 40% of recipients developed BRI with their own bacteria cultured before LT. Purulent sputum appears to be an important factor to discriminate tracheobronchitis from pneumonia. When compared to patients with tracheobronchitis, those with pneumonia had longer durations of mechanical ventilation (13 [3–27] vs 3 [29], p = 0.0005) and ICU stay (24 [16–34] vs 14 [9-22], p = 0.002). Pneumonia was associated with higher 28-day (11 (32%) vs 9 (7%), p = 0.0004) and one-year mortality rates (21 (61%) vs 24 (19%), p ≤ 0.0001). Conclusions These data confirm the high frequency of BRI right from the early postoperative period and the poor prognosis of pneumonia after LT. |
topic |
Lung transplantation Pneumonia Bronchitis Mortality ICU |
url |
http://link.springer.com/article/10.1186/s12890-018-0605-9 |
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