Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review
The gut microbiota have gained much scientific attention recently. Apart from unravelling the taxonomic data, we should understand how the altered microbiota structure corresponds to functions of this complex ecosystem. The metabolites of intestinal microorganisms, especially bacteria, exert pleiotr...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/12/11/3369 |
id |
doaj-208ea75d27a1466e9faa6b24cc65ab5c |
---|---|
record_format |
Article |
spelling |
doaj-208ea75d27a1466e9faa6b24cc65ab5c2020-11-25T03:44:33ZengMDPI AGNutrients2072-66432020-11-01123369336910.3390/nu12113369Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping ReviewKarolina Skonieczna-Żydecka0Karolina Jakubczyk1Dominika Maciejewska-Markiewicz2Katarzyna Janda3Karolina Kaźmierczak-Siedlecka4Mariusz Kaczmarczyk5Igor Łoniewski6and Wojciech Marlicz7Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Surgical Oncology, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdańsk, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Surgical Oncology, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdańsk, PolandDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Gastroenterology, Pomeranian Medical University, 71-252 Szczecin, PolandThe gut microbiota have gained much scientific attention recently. Apart from unravelling the taxonomic data, we should understand how the altered microbiota structure corresponds to functions of this complex ecosystem. The metabolites of intestinal microorganisms, especially bacteria, exert pleiotropic effects on the human organism and contribute to the host systemic balance. These molecules play key roles in regulating immune and metabolic processes. A subset of them affect the gut brain axis signaling and balance the mental wellbeing. Neurotransmitters, short chain fatty acids, tryptophan catabolites, bile acids and phosphatidylcholine, choline, serotonin, and <i>L</i>-carnitine metabolites possess high neuroactive potential. A scoping literature search in PubMed/Embase was conducted up until 20 June 2020, using three major search terms “microbiota metabolites” AND “gut brain axis” AND “mental health”. This review aimed to enhance our knowledge regarding the gut microbiota functional capacity, and support current and future attempts to create new compounds for future clinical interventions.https://www.mdpi.com/2072-6643/12/11/3369microbiometryptophanneurotransmittersshort chain fatty acidsbrain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karolina Skonieczna-Żydecka Karolina Jakubczyk Dominika Maciejewska-Markiewicz Katarzyna Janda Karolina Kaźmierczak-Siedlecka Mariusz Kaczmarczyk Igor Łoniewski and Wojciech Marlicz |
spellingShingle |
Karolina Skonieczna-Żydecka Karolina Jakubczyk Dominika Maciejewska-Markiewicz Katarzyna Janda Karolina Kaźmierczak-Siedlecka Mariusz Kaczmarczyk Igor Łoniewski and Wojciech Marlicz Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review Nutrients microbiome tryptophan neurotransmitters short chain fatty acids brain |
author_facet |
Karolina Skonieczna-Żydecka Karolina Jakubczyk Dominika Maciejewska-Markiewicz Katarzyna Janda Karolina Kaźmierczak-Siedlecka Mariusz Kaczmarczyk Igor Łoniewski and Wojciech Marlicz |
author_sort |
Karolina Skonieczna-Żydecka |
title |
Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review |
title_short |
Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review |
title_full |
Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review |
title_fullStr |
Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review |
title_full_unstemmed |
Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review |
title_sort |
gut biofactory—neurocompetent metabolites within the gastrointestinal tract. a scoping review |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-11-01 |
description |
The gut microbiota have gained much scientific attention recently. Apart from unravelling the taxonomic data, we should understand how the altered microbiota structure corresponds to functions of this complex ecosystem. The metabolites of intestinal microorganisms, especially bacteria, exert pleiotropic effects on the human organism and contribute to the host systemic balance. These molecules play key roles in regulating immune and metabolic processes. A subset of them affect the gut brain axis signaling and balance the mental wellbeing. Neurotransmitters, short chain fatty acids, tryptophan catabolites, bile acids and phosphatidylcholine, choline, serotonin, and <i>L</i>-carnitine metabolites possess high neuroactive potential. A scoping literature search in PubMed/Embase was conducted up until 20 June 2020, using three major search terms “microbiota metabolites” AND “gut brain axis” AND “mental health”. This review aimed to enhance our knowledge regarding the gut microbiota functional capacity, and support current and future attempts to create new compounds for future clinical interventions. |
topic |
microbiome tryptophan neurotransmitters short chain fatty acids brain |
url |
https://www.mdpi.com/2072-6643/12/11/3369 |
work_keys_str_mv |
AT karolinaskoniecznazydecka gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview AT karolinajakubczyk gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview AT dominikamaciejewskamarkiewicz gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview AT katarzynajanda gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview AT karolinakazmierczaksiedlecka gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview AT mariuszkaczmarczyk gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview AT igorłoniewski gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview AT andwojciechmarlicz gutbiofactoryneurocompetentmetaboliteswithinthegastrointestinaltractascopingreview |
_version_ |
1724514214423298048 |