Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology
The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cel...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-09-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/18/6658 |
id |
doaj-20b9983ed42849d7b6392d3e88fccdf2 |
---|---|
record_format |
Article |
spelling |
doaj-20b9983ed42849d7b6392d3e88fccdf22020-11-25T01:26:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01216658665810.3390/ijms21186658Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell BiologyAthina A. Kyriazi0Efstathios Papiris1Konstantinos Kitsos Kalyvianakis2George Sakellaris3Stavroula Baritaki4Laboratory of Experimental Oncology, Division of Surgery, School of Medicine, University of Crete, 71500 Heraklion, GreeceLaboratory of Experimental Oncology, Division of Surgery, School of Medicine, University of Crete, 71500 Heraklion, GreeceLaboratory of Experimental Oncology, Division of Surgery, School of Medicine, University of Crete, 71500 Heraklion, GreeceSurgery Unit, University General Hospital, 71500 Heraklion (PAGNH), GreeceLaboratory of Experimental Oncology, Division of Surgery, School of Medicine, University of Crete, 71500 Heraklion, GreeceThe identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, and therapeutic targets. Given the CSC plasticity, the identification of CSC-related biomarkers has been a serious burden in CSC characterization and therapeutic targeting. Over the past decades, a compelling amount of evidence has demonstrated critical regulatory functions of non-coding RNAs (ncRNAs) on the exclusive features of CSCs. We now know that ncRNAs may interfere with signaling pathways, vital for CSC phenotype maintenance, such as Notch, Wnt, and Hedgehog. Here, we discuss the multifaceted contribution of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types. We further discuss the use of CSC-related ncRNAs as putative biomarkers of high diagnostic, prognostic, and therapeutic value.https://www.mdpi.com/1422-0067/21/18/6658cancer stem cellslong non coding RNAsmicro-RNAscircular RNAscancer metastasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Athina A. Kyriazi Efstathios Papiris Konstantinos Kitsos Kalyvianakis George Sakellaris Stavroula Baritaki |
spellingShingle |
Athina A. Kyriazi Efstathios Papiris Konstantinos Kitsos Kalyvianakis George Sakellaris Stavroula Baritaki Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology International Journal of Molecular Sciences cancer stem cells long non coding RNAs micro-RNAs circular RNAs cancer metastasis |
author_facet |
Athina A. Kyriazi Efstathios Papiris Konstantinos Kitsos Kalyvianakis George Sakellaris Stavroula Baritaki |
author_sort |
Athina A. Kyriazi |
title |
Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology |
title_short |
Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology |
title_full |
Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology |
title_fullStr |
Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology |
title_full_unstemmed |
Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology |
title_sort |
dual effects of non-coding rnas (ncrnas) in cancer stem cell biology |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-09-01 |
description |
The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, and therapeutic targets. Given the CSC plasticity, the identification of CSC-related biomarkers has been a serious burden in CSC characterization and therapeutic targeting. Over the past decades, a compelling amount of evidence has demonstrated critical regulatory functions of non-coding RNAs (ncRNAs) on the exclusive features of CSCs. We now know that ncRNAs may interfere with signaling pathways, vital for CSC phenotype maintenance, such as Notch, Wnt, and Hedgehog. Here, we discuss the multifaceted contribution of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types. We further discuss the use of CSC-related ncRNAs as putative biomarkers of high diagnostic, prognostic, and therapeutic value. |
topic |
cancer stem cells long non coding RNAs micro-RNAs circular RNAs cancer metastasis |
url |
https://www.mdpi.com/1422-0067/21/18/6658 |
work_keys_str_mv |
AT athinaakyriazi dualeffectsofnoncodingrnasncrnasincancerstemcellbiology AT efstathiospapiris dualeffectsofnoncodingrnasncrnasincancerstemcellbiology AT konstantinoskitsoskalyvianakis dualeffectsofnoncodingrnasncrnasincancerstemcellbiology AT georgesakellaris dualeffectsofnoncodingrnasncrnasincancerstemcellbiology AT stavroulabaritaki dualeffectsofnoncodingrnasncrnasincancerstemcellbiology |
_version_ |
1725109240032395264 |