The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases

The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases

This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/o...

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Main Authors: Beichen Jiang, Jackob Moskovitz
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Antioxidants
Subjects:
methionine sulfoxide reductase
methionine oxidation
oxidative stress
Online Access:http://www.mdpi.com/2076-3921/7/9/122
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spelling doaj-20c7d7896fbd4576ac4b71598c2ab20e2020-11-25T00:57:53ZengMDPI AGAntioxidants2076-39212018-09-017912210.3390/antiox7090122antiox7090122The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related DiseasesBeichen Jiang0Jackob Moskovitz1Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USADepartment of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USAThis review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated.http://www.mdpi.com/2076-3921/7/9/122methionine sulfoxide reductasemethionine oxidationoxidative stress
collection DOAJ
language English
format Article
sources DOAJ
author Beichen Jiang
Jackob Moskovitz
spellingShingle Beichen Jiang
Jackob Moskovitz
The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
Antioxidants
methionine sulfoxide reductase
methionine oxidation
oxidative stress
author_facet Beichen Jiang
Jackob Moskovitz
author_sort Beichen Jiang
title The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_short The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_full The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_fullStr The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_full_unstemmed The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_sort functions of the mammalian methionine sulfoxide reductase system and related diseases
publisher MDPI AG
series Antioxidants
issn 2076-3921
publishDate 2018-09-01
description This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated.
topic methionine sulfoxide reductase
methionine oxidation
oxidative stress
url http://www.mdpi.com/2076-3921/7/9/122
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