Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides
Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds i...
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doaj-20c9e44e201a4687ae663e4255ec19622020-11-25T02:43:10ZengMDPI AGMolecules1420-30492017-11-012212206910.3390/molecules22122069molecules22122069Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding CyclodipeptidesXiaohan Wang0Minyi Lin1Dan Xu2Daowan Lai3Ligang Zhou4Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaCyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds in the core ring) reported until August 2017. About 293 cyclic peptides belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, undeca-, dodeca-, tetradeca-, and octadecapeptides as well as cyclic peptides containing ether bonds in the core ring have been isolated from fungi. They were mainly isolated from the genera Aspergillus, Penicillium, Fusarium, Acremonium and Amanita. Some of them were screened to have antimicrobial, antiviral, cytotoxic, phytotoxic, insecticidal, nematicidal, immunosuppressive and enzyme-inhibitory activities to show their potential applications. Some fungal cyclic peptides such as the echinocandins, pneumocandins and cyclosporin A have been developed as pharmaceuticals.https://www.mdpi.com/1420-3049/22/12/2069cyclopeptidesfungibiological activitiesoccurrenceapplications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaohan Wang Minyi Lin Dan Xu Daowan Lai Ligang Zhou |
spellingShingle |
Xiaohan Wang Minyi Lin Dan Xu Daowan Lai Ligang Zhou Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides Molecules cyclopeptides fungi biological activities occurrence applications |
author_facet |
Xiaohan Wang Minyi Lin Dan Xu Daowan Lai Ligang Zhou |
author_sort |
Xiaohan Wang |
title |
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides |
title_short |
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides |
title_full |
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides |
title_fullStr |
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides |
title_full_unstemmed |
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides |
title_sort |
structural diversity and biological activities of fungal cyclic peptides, excluding cyclodipeptides |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-11-01 |
description |
Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds in the core ring) reported until August 2017. About 293 cyclic peptides belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, undeca-, dodeca-, tetradeca-, and octadecapeptides as well as cyclic peptides containing ether bonds in the core ring have been isolated from fungi. They were mainly isolated from the genera Aspergillus, Penicillium, Fusarium, Acremonium and Amanita. Some of them were screened to have antimicrobial, antiviral, cytotoxic, phytotoxic, insecticidal, nematicidal, immunosuppressive and enzyme-inhibitory activities to show their potential applications. Some fungal cyclic peptides such as the echinocandins, pneumocandins and cyclosporin A have been developed as pharmaceuticals. |
topic |
cyclopeptides fungi biological activities occurrence applications |
url |
https://www.mdpi.com/1420-3049/22/12/2069 |
work_keys_str_mv |
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