Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells
The aminoethyl−chitooligosaccharide (AE-COS) was reported to inhibit human gastric cancer cell proliferation and human fibrosarcoma cell invasion. In this study, the role of AE-COS in down-regulation of proliferation of human lung A549 cancer cells was evaluated. It was found that AE-COS w...
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doaj-20d1e8bbec0c47f3a5c9be6b4c7a9a702020-11-25T02:01:43ZengMDPI AGBiomolecules2218-273X2019-05-019519510.3390/biom9050195biom9050195Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer CellsDai Hung Ngo0Dai Nghiep Ngo1Se-Kwon Kim2Thanh Sang Vo3Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong province, VietnamDepartment of Biochemistry, Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, VietnamDepartment of Marine Life Science, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 606-791, South KoreaNTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, VietnamThe aminoethyl−chitooligosaccharide (AE-COS) was reported to inhibit human gastric cancer cell proliferation and human fibrosarcoma cell invasion. In this study, the role of AE-COS in down-regulation of proliferation of human lung A549 cancer cells was evaluated. It was found that AE-COS was able to reduce A549 cell proliferation to (32 ± 1.3)% at a concentration of 500 µg/mL. Moreover, AE-COS treatment caused suppression on COX-2 expression in a dose-dependent manner. Notably, the role of AE-COS in induction of cell apoptosis was observed via decreasing Bcl-2 expression and increasing caspase-3 and -9 activation. Accordingly, the antiproliferative effect of AE-COS was indicated due to suppression of cell proliferation and induction of cell apoptosis, suggesting AE-COS as a promising chemotherapy agent for treatment of lung cancer.https://www.mdpi.com/2218-273X/9/5/195chitooligosaccharideproliferationapoptosisA549 cellscaspase-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dai Hung Ngo Dai Nghiep Ngo Se-Kwon Kim Thanh Sang Vo |
spellingShingle |
Dai Hung Ngo Dai Nghiep Ngo Se-Kwon Kim Thanh Sang Vo Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells Biomolecules chitooligosaccharide proliferation apoptosis A549 cells caspase-3 |
author_facet |
Dai Hung Ngo Dai Nghiep Ngo Se-Kwon Kim Thanh Sang Vo |
author_sort |
Dai Hung Ngo |
title |
Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells |
title_short |
Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells |
title_full |
Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells |
title_fullStr |
Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells |
title_full_unstemmed |
Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells |
title_sort |
antiproliferative effect of aminoethyl-chitooligosaccharide on human lung a549 cancer cells |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2019-05-01 |
description |
The aminoethyl−chitooligosaccharide (AE-COS) was reported to inhibit human gastric cancer cell proliferation and human fibrosarcoma cell invasion. In this study, the role of AE-COS in down-regulation of proliferation of human lung A549 cancer cells was evaluated. It was found that AE-COS was able to reduce A549 cell proliferation to (32 ± 1.3)% at a concentration of 500 µg/mL. Moreover, AE-COS treatment caused suppression on COX-2 expression in a dose-dependent manner. Notably, the role of AE-COS in induction of cell apoptosis was observed via decreasing Bcl-2 expression and increasing caspase-3 and -9 activation. Accordingly, the antiproliferative effect of AE-COS was indicated due to suppression of cell proliferation and induction of cell apoptosis, suggesting AE-COS as a promising chemotherapy agent for treatment of lung cancer. |
topic |
chitooligosaccharide proliferation apoptosis A549 cells caspase-3 |
url |
https://www.mdpi.com/2218-273X/9/5/195 |
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