Targeted Molecular Treatments in Non-Small Cell Lung Cancer: A Clinical Guide for Oncologists

• Main Authors: Kim Tam Bui, Wendy A. Cooper, Steven Kao, Michael Boyer
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: Journal of Clinical Medicine
• Subjects: personalized therapy; non-small cell; lung cancer; targeted therapy; mutation; rearrangement
• Online Access: http://www.mdpi.com/2077-0383/7/8/192

Targeted molecular treatments have changed the way non-small cell lung cancer (NSCLC) is managed. Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), and c-ros oncogene 1 (ROS1) mutations are now used to guide specific anti-cancer therapies to improve patient outcomes. New targeted molecular treatments are constantly being developed and evaluated as a means to improve efficacy, overcome resistance, or minimise toxicity. This review article summarises the current evidence for the efficacy, resistance mechanisms, and safety of targeted molecular treatments against specific mutations in NSCLC.