The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish
Gonadotropin-inhibitory hormone, GnIH, is named because of its function in birds and mammals; however, in other vertebrates this function is not yet clearly established. More than half of the vertebrate species are teleosts. This group is characterized by the 3R whole genome duplication, a fact that...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-02-01
|
Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00078/full |
id |
doaj-20d9b73e889c429ebf4c1c417652313b |
---|---|
record_format |
Article |
spelling |
doaj-20d9b73e889c429ebf4c1c417652313b2020-11-24T22:01:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-02-011010.3389/fendo.2019.00078440593The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From FishMaría P. Di Yorio0María P. Di Yorio1José A. Muñoz-Cueto2José A. Muñoz-Cueto3José A. Paullada-Salmerón4José A. Paullada-Salmerón5Gustavo M. Somoza6Kazuyoshi Tsutsui7Paula G. Vissio8Paula G. Vissio9Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, ArgentinaInstituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, ArgentinaDepartment of Biology, Faculty of Marine and Environmental Sciences, University of Cádiz, Puerto Real, SpainMarine Research Institute (INMAR), Marine Campus of International Excellence (CEIMAR) and Agrifood Campus of International Excellence (ceiA3), Puerto Real, SpainDepartment of Biology, Faculty of Marine and Environmental Sciences, University of Cádiz, Puerto Real, SpainMarine Research Institute (INMAR), Marine Campus of International Excellence (CEIMAR) and Agrifood Campus of International Excellence (ceiA3), Puerto Real, SpainInstituto Tecnológico de Chascomús (CONICET-UNSAM), Chascomús, ArgentinaDepartment of Biology and Center for Medical Life Science, Waseda University, Tokyo, JapanDepartamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, ArgentinaInstituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, ArgentinaGonadotropin-inhibitory hormone, GnIH, is named because of its function in birds and mammals; however, in other vertebrates this function is not yet clearly established. More than half of the vertebrate species are teleosts. This group is characterized by the 3R whole genome duplication, a fact that could have been responsible for the great phenotypic complexity and great variability in reproductive strategies and sexual behavior. In this context, we revise GnIH cell bodies and fibers distribution in adult brains of teleosts, discuss its relationship with GnRH variants and summarize the few reports available about the ontogeny of the GnIH system. Considering all the information presented in this review, we propose that in teleosts, GnIH could have other functions beyond reproduction or act as an integrative signal in the reproductive process. However, further studies are required in order to clarify the role of GnIH in this group including its involvement in development, a key stage that strongly impacts on adult life.https://www.frontiersin.org/article/10.3389/fendo.2019.00078/fullGnIHfishbrainontogenyGnRHgrowth |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María P. Di Yorio María P. Di Yorio José A. Muñoz-Cueto José A. Muñoz-Cueto José A. Paullada-Salmerón José A. Paullada-Salmerón Gustavo M. Somoza Kazuyoshi Tsutsui Paula G. Vissio Paula G. Vissio |
spellingShingle |
María P. Di Yorio María P. Di Yorio José A. Muñoz-Cueto José A. Muñoz-Cueto José A. Paullada-Salmerón José A. Paullada-Salmerón Gustavo M. Somoza Kazuyoshi Tsutsui Paula G. Vissio Paula G. Vissio The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish Frontiers in Endocrinology GnIH fish brain ontogeny GnRH growth |
author_facet |
María P. Di Yorio María P. Di Yorio José A. Muñoz-Cueto José A. Muñoz-Cueto José A. Paullada-Salmerón José A. Paullada-Salmerón Gustavo M. Somoza Kazuyoshi Tsutsui Paula G. Vissio Paula G. Vissio |
author_sort |
María P. Di Yorio |
title |
The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish |
title_short |
The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish |
title_full |
The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish |
title_fullStr |
The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish |
title_full_unstemmed |
The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish |
title_sort |
gonadotropin-inhibitory hormone: what we know and what we still have to learn from fish |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2019-02-01 |
description |
Gonadotropin-inhibitory hormone, GnIH, is named because of its function in birds and mammals; however, in other vertebrates this function is not yet clearly established. More than half of the vertebrate species are teleosts. This group is characterized by the 3R whole genome duplication, a fact that could have been responsible for the great phenotypic complexity and great variability in reproductive strategies and sexual behavior. In this context, we revise GnIH cell bodies and fibers distribution in adult brains of teleosts, discuss its relationship with GnRH variants and summarize the few reports available about the ontogeny of the GnIH system. Considering all the information presented in this review, we propose that in teleosts, GnIH could have other functions beyond reproduction or act as an integrative signal in the reproductive process. However, further studies are required in order to clarify the role of GnIH in this group including its involvement in development, a key stage that strongly impacts on adult life. |
topic |
GnIH fish brain ontogeny GnRH growth |
url |
https://www.frontiersin.org/article/10.3389/fendo.2019.00078/full |
work_keys_str_mv |
AT mariapdiyorio thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT mariapdiyorio thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseamunozcueto thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseamunozcueto thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseapaulladasalmeron thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseapaulladasalmeron thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT gustavomsomoza thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT kazuyoshitsutsui thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT paulagvissio thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT paulagvissio thegonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT mariapdiyorio gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT mariapdiyorio gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseamunozcueto gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseamunozcueto gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseapaulladasalmeron gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT joseapaulladasalmeron gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT gustavomsomoza gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT kazuyoshitsutsui gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT paulagvissio gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish AT paulagvissio gonadotropininhibitoryhormonewhatweknowandwhatwestillhavetolearnfromfish |
_version_ |
1725838778562510848 |