Effects of treadmill running with different intensity on rat subchondral bone
Abstract Subchondral bone (SB) is recognized as a key factor in normal joint protection, not only does it provide a shock absorbing and supportive function for the cartilage, but it may also be important for cartilage metabolism. Mechanical loading is considered to be a critical regulator of skeleta...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-05-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-02126-z |
id |
doaj-20da57da062a4b3cae24a52f897dbb55 |
---|---|
record_format |
Article |
spelling |
doaj-20da57da062a4b3cae24a52f897dbb552020-12-08T02:48:24ZengNature Publishing GroupScientific Reports2045-23222017-05-017111010.1038/s41598-017-02126-zEffects of treadmill running with different intensity on rat subchondral boneZhe Li0Sheng-Yao Liu1Lei Xu2Shao-Yong Xu3Guo-Xin Ni4Department of Orthopaedics and Traumatology, Zhengzhou Orthopaedics HospitalDepartment of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical UniversityDepartment of Rehabilitation Medicine, First Affiliated Hospital, Fujian Medical UniversityAbstract Subchondral bone (SB) is recognized as a key factor in normal joint protection, not only does it provide a shock absorbing and supportive function for the cartilage, but it may also be important for cartilage metabolism. Mechanical loading is considered to be a critical regulator of skeletal homeostasis, including bone and cartilage. It is suggested that both cartilage and bone may respond to mechanical loading in an intensity-dependent manner. In this report, we have discovered that the subchondral plate became thicker with higher bone mineral density (BMD) and lower porosity, while trabecular bone became more plate-like and denser with higher BMD in high-intensity running (HIR) group. Further, HIR led to highly remodeled, less mineralized, and stiffer subchondral plate and trabecular bone. On the contrary, low-intensity running and moderate-intensity running failed to result in considerable changes in microstructure, composition and hardness. Our findings suggested that running affects SB in an intensity-dependent manner. In addition, HIR may induce change in organization and composition of SB, and consequently alter its mechanical properties. HIR-induced “brittle and stiff” SB may adversely affect the overlying articular cartilage.https://doi.org/10.1038/s41598-017-02126-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhe Li Sheng-Yao Liu Lei Xu Shao-Yong Xu Guo-Xin Ni |
spellingShingle |
Zhe Li Sheng-Yao Liu Lei Xu Shao-Yong Xu Guo-Xin Ni Effects of treadmill running with different intensity on rat subchondral bone Scientific Reports |
author_facet |
Zhe Li Sheng-Yao Liu Lei Xu Shao-Yong Xu Guo-Xin Ni |
author_sort |
Zhe Li |
title |
Effects of treadmill running with different intensity on rat subchondral bone |
title_short |
Effects of treadmill running with different intensity on rat subchondral bone |
title_full |
Effects of treadmill running with different intensity on rat subchondral bone |
title_fullStr |
Effects of treadmill running with different intensity on rat subchondral bone |
title_full_unstemmed |
Effects of treadmill running with different intensity on rat subchondral bone |
title_sort |
effects of treadmill running with different intensity on rat subchondral bone |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-05-01 |
description |
Abstract Subchondral bone (SB) is recognized as a key factor in normal joint protection, not only does it provide a shock absorbing and supportive function for the cartilage, but it may also be important for cartilage metabolism. Mechanical loading is considered to be a critical regulator of skeletal homeostasis, including bone and cartilage. It is suggested that both cartilage and bone may respond to mechanical loading in an intensity-dependent manner. In this report, we have discovered that the subchondral plate became thicker with higher bone mineral density (BMD) and lower porosity, while trabecular bone became more plate-like and denser with higher BMD in high-intensity running (HIR) group. Further, HIR led to highly remodeled, less mineralized, and stiffer subchondral plate and trabecular bone. On the contrary, low-intensity running and moderate-intensity running failed to result in considerable changes in microstructure, composition and hardness. Our findings suggested that running affects SB in an intensity-dependent manner. In addition, HIR may induce change in organization and composition of SB, and consequently alter its mechanical properties. HIR-induced “brittle and stiff” SB may adversely affect the overlying articular cartilage. |
url |
https://doi.org/10.1038/s41598-017-02126-z |
work_keys_str_mv |
AT zheli effectsoftreadmillrunningwithdifferentintensityonratsubchondralbone AT shengyaoliu effectsoftreadmillrunningwithdifferentintensityonratsubchondralbone AT leixu effectsoftreadmillrunningwithdifferentintensityonratsubchondralbone AT shaoyongxu effectsoftreadmillrunningwithdifferentintensityonratsubchondralbone AT guoxinni effectsoftreadmillrunningwithdifferentintensityonratsubchondralbone |
_version_ |
1724393303766466560 |