Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson’s Disease-Linked PARK7

Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson’s Disease-Linked PARK7

Although a loss-of-function mutation has been identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we identified UCP0045037 as a compound that bound to the reduced form of DJ-1 by in silico virtual screenin...

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Bibliographic Details
Main Authors: Takahiro Taira, Takashi Taniguchi, Daijiro Yanagisawa, Kazuyuki Takata, Yoshihisa Kitamura, Takashi Yanagida, Koichiro Yamane, Hiroyoshi Ariga
Format: Article
Language:English
Published: MDPI AG 2009-11-01
Series:International Journal of Molecular Sciences
Subjects:
DJ-1
allosteric modulator
neuroprotection
anti-oxidative response
in silico virtual screening
in vivo rat brain
in vitro neuronal culture
Online Access:http://www.mdpi.com/1422-0067/10/11/4789/

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