Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer

Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer

Tumor lysis syndrome (TLS) is an oncological life-threatening complication characterized by hyperuricemia, hyperphosphatemia, and hyperkalemia, which can lead to acute renal failure, cardiac arrhythmias, cardiac arrest and seizures. Although TLS is a rare complication in patients with non-hematologi...

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Main Authors: Tomomichi Ito, Tsuyoshi Ohta, Megumi Narumi, Hirotsugu Sakaki, Manabu Seino, Takeshi Sudo, Satoru Nagase
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Gynecologic Oncology Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S235257891830016X
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spelling doaj-20fb1acfbe794e90b6326f53ad1995a72020-11-25T01:04:28ZengElsevierGynecologic Oncology Reports2352-57892018-05-01242123Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancerTomomichi Ito0Tsuyoshi Ohta1Megumi Narumi2Hirotsugu Sakaki3Manabu Seino4Takeshi Sudo5Satoru Nagase6Department of Obstetrics and Gynecology, Yamagata University, Faculty of medicine, Iidanishi 2-2-2, Yamagata 990-9585, JapanCorresponding author.; Department of Obstetrics and Gynecology, Yamagata University, Faculty of medicine, Iidanishi 2-2-2, Yamagata 990-9585, JapanDepartment of Obstetrics and Gynecology, Yamagata University, Faculty of medicine, Iidanishi 2-2-2, Yamagata 990-9585, JapanDepartment of Obstetrics and Gynecology, Yamagata University, Faculty of medicine, Iidanishi 2-2-2, Yamagata 990-9585, JapanDepartment of Obstetrics and Gynecology, Yamagata University, Faculty of medicine, Iidanishi 2-2-2, Yamagata 990-9585, JapanDepartment of Obstetrics and Gynecology, Yamagata University, Faculty of medicine, Iidanishi 2-2-2, Yamagata 990-9585, JapanDepartment of Obstetrics and Gynecology, Yamagata University, Faculty of medicine, Iidanishi 2-2-2, Yamagata 990-9585, JapanTumor lysis syndrome (TLS) is an oncological life-threatening complication characterized by hyperuricemia, hyperphosphatemia, and hyperkalemia, which can lead to acute renal failure, cardiac arrhythmias, cardiac arrest and seizures. Although TLS is a rare complication in patients with non-hematological malignancy, the mortality rate of TLS in solid tumors is higher than that in hematological malignancies. Acute renal injury is the most common cause of mortality associated with TLS in solid tumors. We report a case of TLS following chemotherapy for a recurrent uterine serous carcinoma. In this case, we speculated that the cause of death might be a pulmonary tumor embolism caused by TLS. Keywords: Tumor lysis syndrome, Endometrial cancer, Pulmonary tumor embolismhttp://www.sciencedirect.com/science/article/pii/S235257891830016X
collection DOAJ
language English
format Article
sources DOAJ
author Tomomichi Ito
Tsuyoshi Ohta
Megumi Narumi
Hirotsugu Sakaki
Manabu Seino
Takeshi Sudo
Satoru Nagase
spellingShingle Tomomichi Ito
Tsuyoshi Ohta
Megumi Narumi
Hirotsugu Sakaki
Manabu Seino
Takeshi Sudo
Satoru Nagase
Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
Gynecologic Oncology Reports
author_facet Tomomichi Ito
Tsuyoshi Ohta
Megumi Narumi
Hirotsugu Sakaki
Manabu Seino
Takeshi Sudo
Satoru Nagase
author_sort Tomomichi Ito
title Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
title_short Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
title_full Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
title_fullStr Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
title_full_unstemmed Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
title_sort tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
publisher Elsevier
series Gynecologic Oncology Reports
issn 2352-5789
publishDate 2018-05-01
description Tumor lysis syndrome (TLS) is an oncological life-threatening complication characterized by hyperuricemia, hyperphosphatemia, and hyperkalemia, which can lead to acute renal failure, cardiac arrhythmias, cardiac arrest and seizures. Although TLS is a rare complication in patients with non-hematological malignancy, the mortality rate of TLS in solid tumors is higher than that in hematological malignancies. Acute renal injury is the most common cause of mortality associated with TLS in solid tumors. We report a case of TLS following chemotherapy for a recurrent uterine serous carcinoma. In this case, we speculated that the cause of death might be a pulmonary tumor embolism caused by TLS. Keywords: Tumor lysis syndrome, Endometrial cancer, Pulmonary tumor embolism
url http://www.sciencedirect.com/science/article/pii/S235257891830016X
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AT meguminarumi tumorlysissyndromeassociatedwithdocetaxelandcarboplatininacasewithrecurrentendometrialcancer
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