Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension
<p>Abstract</p> <p>Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. S...
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doaj-20fc1af096db421c8ad6177212d686342020-11-24T21:25:20ZengBMCEuropean Journal of Medical Research2047-783X2009-09-01141043310.1186/2047-783X-14-10-433Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertensionSweeney LoriVoelkel Norbert F<p>Abstract</p> <p>Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of thyroid disease in these patients, but no studies have evaluated for a coexistence of endocrine factors. In particular, no studies have attempted to evaluate for concurrent thyroid disease, obesity and long-term estrogen exposure in patients.</p> <p>88 patients attending the Pulmonary Hypertension Association 8th International meeting completed a questionnaire and were interviewed. Information was collected regarding reproductive history, height, weight, and previous diagnosis of thyroid disease.</p> <p>46% met criteria for obesity. 41% reported a diagnosis of thyroid disease. 81% of women reported prior use of hormone therapy. 70% reported greater than 10 years of exogenous hormone use. 74% of female patients reported two or more of potentially disease modifying endocrine factors (obesity, thyroid disease or estrogen therapy).</p> <p>The coexistent high prevalence in our cohort of exogenous estrogen exposure, thyroid disease and obesity suggests that an interaction of multiple endocrine factors might contribute to the pathogenesis of pulmonary hypertension and may represent epigenetic modifiers in genetically-susceptible individuals.</p> http://www.eurjmedres.com/content/14/10/433Severe pulmonary hypertensionEstrogenMenopauseThyroid DiseaseAutoimmunityObesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sweeney Lori Voelkel Norbert F |
spellingShingle |
Sweeney Lori Voelkel Norbert F Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension European Journal of Medical Research Severe pulmonary hypertension Estrogen Menopause Thyroid Disease Autoimmunity Obesity |
author_facet |
Sweeney Lori Voelkel Norbert F |
author_sort |
Sweeney Lori |
title |
Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension |
title_short |
Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension |
title_full |
Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension |
title_fullStr |
Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension |
title_full_unstemmed |
Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension |
title_sort |
estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension |
publisher |
BMC |
series |
European Journal of Medical Research |
issn |
2047-783X |
publishDate |
2009-09-01 |
description |
<p>Abstract</p> <p>Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of thyroid disease in these patients, but no studies have evaluated for a coexistence of endocrine factors. In particular, no studies have attempted to evaluate for concurrent thyroid disease, obesity and long-term estrogen exposure in patients.</p> <p>88 patients attending the Pulmonary Hypertension Association 8th International meeting completed a questionnaire and were interviewed. Information was collected regarding reproductive history, height, weight, and previous diagnosis of thyroid disease.</p> <p>46% met criteria for obesity. 41% reported a diagnosis of thyroid disease. 81% of women reported prior use of hormone therapy. 70% reported greater than 10 years of exogenous hormone use. 74% of female patients reported two or more of potentially disease modifying endocrine factors (obesity, thyroid disease or estrogen therapy).</p> <p>The coexistent high prevalence in our cohort of exogenous estrogen exposure, thyroid disease and obesity suggests that an interaction of multiple endocrine factors might contribute to the pathogenesis of pulmonary hypertension and may represent epigenetic modifiers in genetically-susceptible individuals.</p> |
topic |
Severe pulmonary hypertension Estrogen Menopause Thyroid Disease Autoimmunity Obesity |
url |
http://www.eurjmedres.com/content/14/10/433 |
work_keys_str_mv |
AT sweeneylori estrogenexposureobesityandthyroiddiseaseinwomenwithseverepulmonaryhypertension AT voelkelnorbertf estrogenexposureobesityandthyroiddiseaseinwomenwithseverepulmonaryhypertension |
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