Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets
Background Eosinophilic esophagitis (EoE) is a complex pathology. Attempts have been made in order to relate EoE with the intake of certain food. The problem is to establish which foods are really involved in the pathophysiology of this condition and to objectify a reliable inflammation biomarker fo...
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doaj-21039ef685694fe9b4c9747e281b49de2020-11-25T01:16:11ZengElsevierWorld Allergy Organization Journal1939-45512017-01-01101Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion dietsJoan Doménech Witek0Vicente Jover Cerdà1Vicente Gil Guillén2Juan Bautista Doménech Clar3Ramón Rodríguez Pacheco4Hospital General de Elda, Sección de Alergología. H. Elda, Carretera de Sax, 03600 Elda, Alicante, Spain; Correspondence:Hospital General de Elda, Sección de Alergología. H. Elda, Carretera de Sax, 03600 Elda, Alicante, SpainUniversidad Miguel Hernandez de Elche, Alicante, SpainHospital Universitario Dr. Peset, València, SpainHospital General de Elda, Sección de Alergología. H. Elda, Carretera de Sax, 03600 Elda, Alicante, SpainBackground Eosinophilic esophagitis (EoE) is a complex pathology. Attempts have been made in order to relate EoE with the intake of certain food. The problem is to establish which foods are really involved in the pathophysiology of this condition and to objectify a reliable inflammation biomarker for the follow-up of patients undergoing pharmacological treatment and/or diets. Our aim is to assess the food sensitization profile of patients with objective diagnosis of EoE and objectify the utility of ECP as an inflammation biomarker for the follow-up of patients with EoE treated with specific diets, based on the hypothesis that we will observe a decrease and clinical improvement after maintenance of these diets.Methods A total of 19 subjects were included between 1 January 2012 and 30 June 2015. Diets based on allergy testing were established. Prior to the initiation of the diets, baseline ECP was determined. Appointments were arranged for the patients between 4 and 6 months later to assess the clinical response to the specific diets and to request a second blood sample for blood counts and serum ECP levels to compare with the previous baseline.Results 19 patients diagnosed with EoE (12 males and 7 females) between January 2012 and June 2015, aged between 17 and 68 (33.52; SD 13.67 years), were included consecutively, 15 of whom showed optimum response to specific diets based on allergy testing. A statistically significant difference ECP decrease was observed in our patients.Discussion Until now most of the studies previously published in reference to the use of ECP as a biomarker for monitoring patients on treatment with diets show consistent but insignificant decreases in ECP levels. However, ECP seems to be a good marker of inflammation if the determinations are performed avoiding confounding factors.Conclusion The serial determination of ECP is useful when monitoring patients with EoE treated with specific diets. Keywords: Eosinophilic esophagitis, Eosinophil cationic protein, Specific diethttp://www.sciencedirect.com/science/article/pii/S1939455119300122 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joan Doménech Witek Vicente Jover Cerdà Vicente Gil Guillén Juan Bautista Doménech Clar Ramón Rodríguez Pacheco |
spellingShingle |
Joan Doménech Witek Vicente Jover Cerdà Vicente Gil Guillén Juan Bautista Doménech Clar Ramón Rodríguez Pacheco Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets World Allergy Organization Journal |
author_facet |
Joan Doménech Witek Vicente Jover Cerdà Vicente Gil Guillén Juan Bautista Doménech Clar Ramón Rodríguez Pacheco |
author_sort |
Joan Doménech Witek |
title |
Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets |
title_short |
Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets |
title_full |
Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets |
title_fullStr |
Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets |
title_full_unstemmed |
Assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets |
title_sort |
assessing eosinophilic cationic protein as a biomarker for monitoring patients with eosinophilic esophagitis treated with specific exclusion diets |
publisher |
Elsevier |
series |
World Allergy Organization Journal |
issn |
1939-4551 |
publishDate |
2017-01-01 |
description |
Background Eosinophilic esophagitis (EoE) is a complex pathology. Attempts have been made in order to relate EoE with the intake of certain food. The problem is to establish which foods are really involved in the pathophysiology of this condition and to objectify a reliable inflammation biomarker for the follow-up of patients undergoing pharmacological treatment and/or diets. Our aim is to assess the food sensitization profile of patients with objective diagnosis of EoE and objectify the utility of ECP as an inflammation biomarker for the follow-up of patients with EoE treated with specific diets, based on the hypothesis that we will observe a decrease and clinical improvement after maintenance of these diets.Methods A total of 19 subjects were included between 1 January 2012 and 30 June 2015. Diets based on allergy testing were established. Prior to the initiation of the diets, baseline ECP was determined. Appointments were arranged for the patients between 4 and 6 months later to assess the clinical response to the specific diets and to request a second blood sample for blood counts and serum ECP levels to compare with the previous baseline.Results 19 patients diagnosed with EoE (12 males and 7 females) between January 2012 and June 2015, aged between 17 and 68 (33.52; SD 13.67 years), were included consecutively, 15 of whom showed optimum response to specific diets based on allergy testing. A statistically significant difference ECP decrease was observed in our patients.Discussion Until now most of the studies previously published in reference to the use of ECP as a biomarker for monitoring patients on treatment with diets show consistent but insignificant decreases in ECP levels. However, ECP seems to be a good marker of inflammation if the determinations are performed avoiding confounding factors.Conclusion The serial determination of ECP is useful when monitoring patients with EoE treated with specific diets. Keywords: Eosinophilic esophagitis, Eosinophil cationic protein, Specific diet |
url |
http://www.sciencedirect.com/science/article/pii/S1939455119300122 |
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