Drug targets for lymphatic filariasis: A bioinformatics approach

• Main Authors: Om Prakash Sharma, Yellamandaya Vadlamudi, Arun Gupta Kota, Vikrant Kumar Sinha, Muthuvel Suresh Kumar
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2013-08-01
• Series: Journal of Vector Borne Diseases
• Subjects: Bioinformatics; filariasis drug targets; filariasis elimination programmes; lymphatic filariasis; proteomics and genomics
• Online Access: http://www.mrcindia.org/journal/issues/503155.pdf

This review article discusses the current scenario of the national and international burden due to lymphatic filariasis (LF) and describes the active elimination programmes for LF and their achievements to eradicate this most debilitating disease from the earth. Since, bioinformatics is a rapidly growing field of biological study, and it has an increasingly significant role in various fields of biology. We have reviewed its leading involvement in the filarial research using different approaches of bioinformatics and have summarized available existing drugs and their targets to re-examine and to keep away from the resisting conditions. Moreover, some of the novel drug targets have been assembled for further study to design fresh and better pharmacological therapeutics. Various bioinformatics-based web resources, and databases have been discussed, which may enrich the filarial research.