Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study

• Main Authors: An-le Li, Xiang Fang, Yi-ying Zhang, Qian Peng, Xian-hong Yin
• Format: Article
• Language: English
• Published: BMC 2019-08-01
• Series: Clinical Hypertension
• Subjects: Hypertension; Heritability; Segregation ratio; Familial aggregation
• Online Access: http://link.springer.com/article/10.1186/s40885-019-0122-z

Abstract Background To explore the familial aggregation and heritability of hypertension in Han in Shanghai China. Methods According to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension. Results The prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second- degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first- degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%. Conclusion The distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.