Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases
Lung diseases (LD) are one of the most common causes of death worldwide. Although it is known that chronic airway inflammation and excessive tissue repair are processes associated with LD such as asthma, chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF), their speci...
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doaj-2110d073099345ec895b3724fc2f48942021-01-09T00:04:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-012258358310.3390/ijms22020583Extracellular Vesicles from Airway Secretions: New Insights in Lung DiseasesLaura Pastor0Elisabeth Vera1Jose M. Marin2David Sanz-Rubio3Translational Research Unit, Instituto de Investigación Sanitaria de Aragón (IISAragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainTranslational Research Unit, Instituto de Investigación Sanitaria de Aragón (IISAragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainTranslational Research Unit, Instituto de Investigación Sanitaria de Aragón (IISAragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainTranslational Research Unit, Instituto de Investigación Sanitaria de Aragón (IISAragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainLung diseases (LD) are one of the most common causes of death worldwide. Although it is known that chronic airway inflammation and excessive tissue repair are processes associated with LD such as asthma, chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF), their specific pathways remain unclear. Extracellular vesicles (EVs) are heterogeneous nanoscale membrane vesicles with an important role in cell-to-cell communication. EVs are present in general biofluids as plasma or urine but also in secretions of the airway as bronchoalveolar lavage fluid (BALF), induced sputum (IS), nasal lavage (NL) or pharyngeal lavage. Alterations of airway EV cargo could be crucial for understanding LD. Airway EVs have shown a role in the pathogenesis of some LD such as eosinophil increase in asthma, the promotion of lung cancer in vitro models in COPD and as biomarkers to distinguishing IPF in patients with diffuse lung diseases. In addition, they also have a promising future as therapeutics for LD. In this review, we focus on the importance of airway secretions in LD, the pivotal role of EVs from those secretions on their pathophysiology and their potential for biomarker discovery.https://www.mdpi.com/1422-0067/22/2/583extracellular vesicleCOPDasthmafibrosisinduced sputumnasal lavage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura Pastor Elisabeth Vera Jose M. Marin David Sanz-Rubio |
spellingShingle |
Laura Pastor Elisabeth Vera Jose M. Marin David Sanz-Rubio Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases International Journal of Molecular Sciences extracellular vesicle COPD asthma fibrosis induced sputum nasal lavage |
author_facet |
Laura Pastor Elisabeth Vera Jose M. Marin David Sanz-Rubio |
author_sort |
Laura Pastor |
title |
Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases |
title_short |
Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases |
title_full |
Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases |
title_fullStr |
Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases |
title_full_unstemmed |
Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases |
title_sort |
extracellular vesicles from airway secretions: new insights in lung diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-01-01 |
description |
Lung diseases (LD) are one of the most common causes of death worldwide. Although it is known that chronic airway inflammation and excessive tissue repair are processes associated with LD such as asthma, chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF), their specific pathways remain unclear. Extracellular vesicles (EVs) are heterogeneous nanoscale membrane vesicles with an important role in cell-to-cell communication. EVs are present in general biofluids as plasma or urine but also in secretions of the airway as bronchoalveolar lavage fluid (BALF), induced sputum (IS), nasal lavage (NL) or pharyngeal lavage. Alterations of airway EV cargo could be crucial for understanding LD. Airway EVs have shown a role in the pathogenesis of some LD such as eosinophil increase in asthma, the promotion of lung cancer in vitro models in COPD and as biomarkers to distinguishing IPF in patients with diffuse lung diseases. In addition, they also have a promising future as therapeutics for LD. In this review, we focus on the importance of airway secretions in LD, the pivotal role of EVs from those secretions on their pathophysiology and their potential for biomarker discovery. |
topic |
extracellular vesicle COPD asthma fibrosis induced sputum nasal lavage |
url |
https://www.mdpi.com/1422-0067/22/2/583 |
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