Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines

Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines

Phosphine metal complexes have been recently evaluated in the field of cancer therapy. In this research, the cytotoxic effects of some metal phosphines {[PdCl2((CH2OH)2PCH2)2NCH3] (C1), [RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2), [PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3)} on K562 (human myelogenous leukemia cell...

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Main Authors: Burcu Saygıdeğer Demir, Tuğba Keleş, Osman Serindağ
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2014/717421
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spelling doaj-211364ef26e746b8bfb615506e7f01da2020-11-25T02:34:43ZengHindawi LimitedBioinorganic Chemistry and Applications1565-36331687-479X2014-01-01201410.1155/2014/717421717421Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell LinesBurcu Saygıdeğer Demir0Tuğba Keleş1Osman Serindağ2Department of Chemistry, Science, and Letters Faculty, Osmaniye Korkut Ata University, Fakıuşağı, 80000 Osmaniye, TurkeyDepartment of Chemistry and Chemical Technology, University of Bayburt, 69000 Bayburt, TurkeyScience Institute, Kanuni University, 01170 Adana, TurkeyPhosphine metal complexes have been recently evaluated in the field of cancer therapy. In this research, the cytotoxic effects of some metal phosphines {[PdCl2((CH2OH)2PCH2)2NCH3] (C1), [RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2), [PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3)} on K562 (human myelogenous leukemia cell line) and A549 (adenocarcinomic human alveolar basal epithelial cells) cells were investigated using the MTT test. C1 and C2 are water-soluble metal complexes, which may have some advantages in in vitro and in vivo studies. The effects of the above-mentioned metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPx) (EC: 1.11.1.9), and catalase (Cat) (EC: 1.11.1.6) enzymes were also tested. The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.http://dx.doi.org/10.1155/2014/717421
collection DOAJ
language English
format Article
sources DOAJ
author Burcu Saygıdeğer Demir
Tuğba Keleş
Osman Serindağ
spellingShingle Burcu Saygıdeğer Demir
Tuğba Keleş
Osman Serindağ
Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
Bioinorganic Chemistry and Applications
author_facet Burcu Saygıdeğer Demir
Tuğba Keleş
Osman Serindağ
author_sort Burcu Saygıdeğer Demir
title Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
title_short Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
title_full Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
title_fullStr Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
title_full_unstemmed Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
title_sort antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines
publisher Hindawi Limited
series Bioinorganic Chemistry and Applications
issn 1565-3633
1687-479X
publishDate 2014-01-01
description Phosphine metal complexes have been recently evaluated in the field of cancer therapy. In this research, the cytotoxic effects of some metal phosphines {[PdCl2((CH2OH)2PCH2)2NCH3] (C1), [RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2), [PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3)} on K562 (human myelogenous leukemia cell line) and A549 (adenocarcinomic human alveolar basal epithelial cells) cells were investigated using the MTT test. C1 and C2 are water-soluble metal complexes, which may have some advantages in in vitro and in vivo studies. The effects of the above-mentioned metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPx) (EC: 1.11.1.9), and catalase (Cat) (EC: 1.11.1.6) enzymes were also tested. The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.
url http://dx.doi.org/10.1155/2014/717421
work_keys_str_mv AT burcusaygıdegerdemir antioxidantenzymeinhibitorroleofphosphinemetalcomplexesinlungandleukemiacelllines
AT tugbakeles antioxidantenzymeinhibitorroleofphosphinemetalcomplexesinlungandleukemiacelllines
AT osmanserindag antioxidantenzymeinhibitorroleofphosphinemetalcomplexesinlungandleukemiacelllines
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