Anomalous Dense Liquid Condensates Host the Nucleation of Tumor Suppressor p53 Fibrils
Summary: About half of human cancers are associated with mutations of the tumor suppressor p53. Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-type and mutant p53. The thermodynamic and kinetic mechanisms of p53 aggregation are poorly understood. Here we...
Main Authors: | Mohammad S. Safari, Zhiqing Wang, Kunaal Tailor, Anatoly B. Kolomeisky, Jacinta C. Conrad, Peter G. Vekilov |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-02-01
|
Series: | iScience |
Online Access: | http://www.sciencedirect.com/science/article/pii/S258900421930029X |
Similar Items
-
Adsorption, nucleation,and condensation on substrate surfaces
by: Xu, Zun-Xian, et al.
Published: (1989) -
The Ambiguous Functions of the Precursors That Enable Nonclassical Modes of Olanzapine Nucleation and Growth
by: Monika Warzecha, et al.
Published: (2021-06-01) -
Anomalous Hall effect in dense QCD matter
by: Toshitaka Tatsumi, et al.
Published: (2018-10-01) -
Anomalous effects of dense matter under rotation
by: Xu-Guang Huang, et al.
Published: (2018-02-01) -
Modelling the kinetics of amyloid fibril nucleation
by: Cabriolu, Raffaela
Published: (2012)