Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report
The authors present a case of a female patient a 26-year old pensioner from Zmajevo, who developed skin changes in the neck region, armpits and groins, as well as in submammal folds during the 10 years period. The changes include dark-brown hyperpigmentation associated with sudden eruption of a lar...
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Institute of Oncology, Sremska Kamenica, Serbia
2008-01-01
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doaj-21159f09787f4f62b9c9e4b0b4c124fd2020-11-25T01:33:42ZengInstitute of Oncology, Sremska Kamenica, SerbiaArchive of Oncology0354-73102008-01-01163-4818310.2298/AOO0804081SAcanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case reportStojanović SlobodanJeremić PavlePoljački MirjanaThe authors present a case of a female patient a 26-year old pensioner from Zmajevo, who developed skin changes in the neck region, armpits and groins, as well as in submammal folds during the 10 years period. The changes include dark-brown hyperpigmentation associated with sudden eruption of a large number of benign skin tumors and dark-brown seborrheic keratosis on trunk and extremities. In 1998, after magnetic resonance imaging, primary brain tumor of astrocytoma type with low grade of malignity was discovered in thalamus region. The patient developed the above-mentioned skin changes since then. According to neurosurgical findings, the brain tumor is inoperable, so skin changes are persistent and stationary. Clinical changes correspond to paraneoplastic form of acanthosis nigricans. Numerous skin tumors histopathologically match seborrheic keratosis and reveal the clinical features of the sign of Leser-Trelat. It is interesting that in the same patient there are both, obligatory and optional, paraneoplastic dermatoses associated with malignant brain tumor. http://www.doiserbia.nb.rs/img/doi/0354-7310/2008/0354-73100804081S.pdfAcanthosis NigricansBrain NeoplasmsParaneoplastic SyndromesKeratosisSeborrheic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stojanović Slobodan Jeremić Pavle Poljački Mirjana |
spellingShingle |
Stojanović Slobodan Jeremić Pavle Poljački Mirjana Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report Archive of Oncology Acanthosis Nigricans Brain Neoplasms Paraneoplastic Syndromes Keratosis Seborrheic |
author_facet |
Stojanović Slobodan Jeremić Pavle Poljački Mirjana |
author_sort |
Stojanović Slobodan |
title |
Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report |
title_short |
Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report |
title_full |
Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report |
title_fullStr |
Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report |
title_full_unstemmed |
Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report |
title_sort |
acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: case report |
publisher |
Institute of Oncology, Sremska Kamenica, Serbia |
series |
Archive of Oncology |
issn |
0354-7310 |
publishDate |
2008-01-01 |
description |
The authors present a case of a female patient a 26-year old pensioner from Zmajevo, who developed skin changes in the neck region, armpits and groins, as well as in submammal folds during the 10 years period. The changes include dark-brown hyperpigmentation associated with sudden eruption of a large number of benign skin tumors and dark-brown seborrheic keratosis on trunk and extremities. In 1998, after magnetic resonance imaging, primary brain tumor of astrocytoma type with low grade of malignity was discovered in thalamus region. The patient developed the above-mentioned skin changes since then. According to neurosurgical findings, the brain tumor is inoperable, so skin changes are persistent and stationary. Clinical changes correspond to paraneoplastic form of acanthosis nigricans. Numerous skin tumors histopathologically match seborrheic keratosis and reveal the clinical features of the sign of Leser-Trelat. It is interesting that in the same patient there are both, obligatory and optional, paraneoplastic dermatoses associated with malignant brain tumor. |
topic |
Acanthosis Nigricans Brain Neoplasms Paraneoplastic Syndromes Keratosis Seborrheic |
url |
http://www.doiserbia.nb.rs/img/doi/0354-7310/2008/0354-73100804081S.pdf |
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