Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in context
Background: Gastric bypass surgery is a very effective treatment of obesity and type 2 diabetes. However, very few eligible patients are offered surgery. Some patients also prefer less invasive approaches.We aimed to study the effects of the Sleeveballoon – a new device combining an intragastric bal...
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doaj-21162c45b6534994886d4faae1411e912020-11-25T02:39:02ZengElsevierEBioMedicine2352-39642019-08-0146452462Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in contextJames Casella-Mariolo0Lidia Castagneto-Gissey1Giulia Angelini2Andrea Zoli3Pierluigi Marini4Stefan R. Bornstein5Dimitri J. Pournaras6Francesco Rubino7Carel W. le Roux8Geltrude Mingrone9Giovanni Casella10Department of Surgery, Azienda Ospedaliera S. Camillo Forlanini, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyUniversità Cattolica del S. Cuore, Rome, ItalyUniversità Cattolica del S. Cuore, Rome, ItalyDepartment of Surgery, Azienda Ospedaliera S. Camillo Forlanini, Rome, ItalyDepartment of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany; Diabetes and Nutritional Sciences, King's College London, London, United KingdomNorth Bristol Centre for Weight Loss, Metabolic & Bariatric Surgery, Southmead Hospital, Bristol, UKDiabetes and Nutritional Sciences, King's College London, London, United KingdomDiabetes Complications Research Centre, Conway Institute, University College Dublin, Ireland; Investigative Science, Imperial College London, London, UKUniversità Cattolica del S. Cuore, Rome, Italy; Diabetes and Nutritional Sciences, King's College London, London, United Kingdom; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Correspondence to: G. Mingrone, Department of Diabetes, King's College London, London, UK.Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy; Correspondence to: G. Casella, Department of Surgery, University of Rome “La Sapienza”, Rome, Italy.Background: Gastric bypass surgery is a very effective treatment of obesity and type 2 diabetes. However, very few eligible patients are offered surgery. Some patients also prefer less invasive approaches.We aimed to study the effects of the Sleeveballoon – a new device combining an intragastric balloon with a connecting sleeve, which covers the duodenal and proximal jejunal mucosa – on insulin sensitivity, glycemic control, body weight and body fat distribution. Methods: We compared the effects of Sleeveballoon, Roux-en-Y Gastric-Bypass (RYGB) and sham-operation in 30 high-fat diet (HFD) fed Wistar rats. Whole body and hepatic insulin sensitivity and insulin signaling were studied. Transthoracic echocardiography was performed using a Vevo 2100 system (FUJIFILM VisualSonics Inc., Canada). Gastric emptying was measured using gastrografin. Findings: Hepatic (P = .023) and whole-body (P = .011) insulin sensitivity improved in the Sleeveballoon and RYGB groups compared with sham-operated rats. Body weight reduced in both Sleeveballoon and RYGB groups in comparison to the sham-operated group (503.1 ± 8.9 vs. 614.4 ± 20.6 g, P = .006 and 490.0 ± 17.7 vs. 614.4 ± 20.6 g, P = .006, respectively). Ectopic fat deposition was drastically reduced while glycogen content was increased in both liver and skeletal muscle. Gastric emptying (T1/2) was longer (157.7 ± 29.2 min, P = .007) in the Sleeveballoon than in sham-operated rats (97.1 ± 26.3 min), but shorter in RYGB (3.5 ± 1.1 min, P < .0001). Cardiac function was better in Sleeveballoon and RYGB versus sham-operated rats. Interpretation: The Sleeveballoon reduces peripheral and hepatic insulin resistance, glycaemia, body weight and ectopic fat deposition to a similar level as RYGB, although the contribution of gastric emptying to blood glucose reduction is different. Keywords: Insulin resistance, Minimally invasive surgery, Gastric bypass, Gastric emptying, Obesity, Type 2 diabeteshttp://www.sciencedirect.com/science/article/pii/S2352396419305110 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
James Casella-Mariolo Lidia Castagneto-Gissey Giulia Angelini Andrea Zoli Pierluigi Marini Stefan R. Bornstein Dimitri J. Pournaras Francesco Rubino Carel W. le Roux Geltrude Mingrone Giovanni Casella |
spellingShingle |
James Casella-Mariolo Lidia Castagneto-Gissey Giulia Angelini Andrea Zoli Pierluigi Marini Stefan R. Bornstein Dimitri J. Pournaras Francesco Rubino Carel W. le Roux Geltrude Mingrone Giovanni Casella Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in context EBioMedicine |
author_facet |
James Casella-Mariolo Lidia Castagneto-Gissey Giulia Angelini Andrea Zoli Pierluigi Marini Stefan R. Bornstein Dimitri J. Pournaras Francesco Rubino Carel W. le Roux Geltrude Mingrone Giovanni Casella |
author_sort |
James Casella-Mariolo |
title |
Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in context |
title_short |
Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in context |
title_full |
Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in context |
title_fullStr |
Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in context |
title_full_unstemmed |
Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon deviceResearch in context |
title_sort |
simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the sleeveballoon deviceresearch in context |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2019-08-01 |
description |
Background: Gastric bypass surgery is a very effective treatment of obesity and type 2 diabetes. However, very few eligible patients are offered surgery. Some patients also prefer less invasive approaches.We aimed to study the effects of the Sleeveballoon – a new device combining an intragastric balloon with a connecting sleeve, which covers the duodenal and proximal jejunal mucosa – on insulin sensitivity, glycemic control, body weight and body fat distribution. Methods: We compared the effects of Sleeveballoon, Roux-en-Y Gastric-Bypass (RYGB) and sham-operation in 30 high-fat diet (HFD) fed Wistar rats. Whole body and hepatic insulin sensitivity and insulin signaling were studied. Transthoracic echocardiography was performed using a Vevo 2100 system (FUJIFILM VisualSonics Inc., Canada). Gastric emptying was measured using gastrografin. Findings: Hepatic (P = .023) and whole-body (P = .011) insulin sensitivity improved in the Sleeveballoon and RYGB groups compared with sham-operated rats. Body weight reduced in both Sleeveballoon and RYGB groups in comparison to the sham-operated group (503.1 ± 8.9 vs. 614.4 ± 20.6 g, P = .006 and 490.0 ± 17.7 vs. 614.4 ± 20.6 g, P = .006, respectively). Ectopic fat deposition was drastically reduced while glycogen content was increased in both liver and skeletal muscle. Gastric emptying (T1/2) was longer (157.7 ± 29.2 min, P = .007) in the Sleeveballoon than in sham-operated rats (97.1 ± 26.3 min), but shorter in RYGB (3.5 ± 1.1 min, P < .0001). Cardiac function was better in Sleeveballoon and RYGB versus sham-operated rats. Interpretation: The Sleeveballoon reduces peripheral and hepatic insulin resistance, glycaemia, body weight and ectopic fat deposition to a similar level as RYGB, although the contribution of gastric emptying to blood glucose reduction is different. Keywords: Insulin resistance, Minimally invasive surgery, Gastric bypass, Gastric emptying, Obesity, Type 2 diabetes |
url |
http://www.sciencedirect.com/science/article/pii/S2352396419305110 |
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