Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural...

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Bibliographic Details
Main Authors: Susanna K.P. Lau, Antonio C.P. Wong, Hayes K.H. Luk, Kenneth S.M. Li, Joshua Fung, Zirong He, Flora K.K. Cheng, Tony T.Y. Chan, Stella Chu, Kam Leng Aw-Yong, Terrence C.K. Lau, Kitty S.C. Fung, Patrick C.Y. Woo
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2020-12-01
Series:Emerging Infectious Diseases
Subjects:
coronavirus disease
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
severe acute respiratory syndrome
SARS
viruses
Online Access:https://wwwnc.cdc.gov/eid/article/26/12/20-2308_article
Description
Summary:Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
ISSN:1080-6040
1080-6059

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