Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study
Objective: Combinations of Chinese herbal products (CHPs) are widely used for Parkinson’s disease (PD) in Taiwan. Thereby, we investigated the use of CHPs in patients with PD.Methods: This study was a population-based cohort study that analyzed the data of patients with PD from the National Health I...
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Frontiers Media S.A.
2021-01-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.615657/full |
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English |
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author |
Chien-Hung Lin Hsienhsueh Elley Chiu Szu-Ying Wu Szu-Ying Wu Szu-Ying Wu Shih-Ting Tseng Tzu-Chan Wu Yu-Chiang Hung Yu-Chiang Hung Chung Y. Hsu Hsuan-Ju Chen Hsuan-Ju Chen Sheng-Feng Hsu Sheng-Feng Hsu Chun-En Kuo Chun-En Kuo Wen-Long Hu Wen-Long Hu Wen-Long Hu |
spellingShingle |
Chien-Hung Lin Hsienhsueh Elley Chiu Szu-Ying Wu Szu-Ying Wu Szu-Ying Wu Shih-Ting Tseng Tzu-Chan Wu Yu-Chiang Hung Yu-Chiang Hung Chung Y. Hsu Hsuan-Ju Chen Hsuan-Ju Chen Sheng-Feng Hsu Sheng-Feng Hsu Chun-En Kuo Chun-En Kuo Wen-Long Hu Wen-Long Hu Wen-Long Hu Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study Frontiers in Pharmacology Chaihu-Jia-Longgu-Muli-Tang Chinese herbal products Chinese medicine Parkinson’s disease Uncaria tomentosa (Willd. ex Schult.) DC. |
author_facet |
Chien-Hung Lin Hsienhsueh Elley Chiu Szu-Ying Wu Szu-Ying Wu Szu-Ying Wu Shih-Ting Tseng Tzu-Chan Wu Yu-Chiang Hung Yu-Chiang Hung Chung Y. Hsu Hsuan-Ju Chen Hsuan-Ju Chen Sheng-Feng Hsu Sheng-Feng Hsu Chun-En Kuo Chun-En Kuo Wen-Long Hu Wen-Long Hu Wen-Long Hu |
author_sort |
Chien-Hung Lin |
title |
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study |
title_short |
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study |
title_full |
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study |
title_fullStr |
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study |
title_full_unstemmed |
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study |
title_sort |
chinese herbal products for non-motor symptoms of parkinson’s disease in taiwan: a population-based study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2021-01-01 |
description |
Objective: Combinations of Chinese herbal products (CHPs) are widely used for Parkinson’s disease (PD) in Taiwan. Thereby, we investigated the use of CHPs in patients with PD.Methods: This study was a population-based cohort study that analyzed the data of patients with PD from the National Health Insurance Research Database. A total of 9,117 patients were selected from a random sample of one million individuals included in this database. We used multiple logistic regression models to estimate the adjusted odds ratios of the demographic factors and analyzed the formula and single CHPs commonly used for PD.Results: Traditional Chinese medicine users were more commonly female, younger, of white-collar status, and residents of Central Taiwan. Chaihu-Jia-Longgu-Muli-Tang was the most commonly used formula, followed by Ma-Zi-Ren-Wan and then Shao-Yao-Gan-Cao-Tang. The most commonly used single herb was Uncaria tomentosa (Willd. ex Schult.) DC., followed by Gastrodia elata Blume and then Radix et Rhizoma Rhei (Rheum palmatum L., Rheum tanguticum Maxim. ex Balf., and Rheum officinale Baill.). Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. have shown neuroprotective effects in previous studies, and they have been used for managing non-motor symptoms of PD.Conclusion: Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. are the most commonly used CHPs for PD in Taiwan. Our results revealed the preferences in medication prescriptions for PD. Further studies are warranted to determine the effectiveness of these CHPs for ameliorating the various symptoms of PD, their adverse effects, and the mechanisms underlying their associated neuroprotective effects. |
topic |
Chaihu-Jia-Longgu-Muli-Tang Chinese herbal products Chinese medicine Parkinson’s disease Uncaria tomentosa (Willd. ex Schult.) DC. |
url |
https://www.frontiersin.org/articles/10.3389/fphar.2020.615657/full |
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doaj-211e1056d8da456383c6fcb1298e04762021-01-27T06:07:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-01-011110.3389/fphar.2020.615657615657Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based StudyChien-Hung Lin0Hsienhsueh Elley Chiu1Szu-Ying Wu2Szu-Ying Wu3Szu-Ying Wu4Shih-Ting Tseng5Tzu-Chan Wu6Yu-Chiang Hung7Yu-Chiang Hung8Chung Y. Hsu9Hsuan-Ju Chen10Hsuan-Ju Chen11Sheng-Feng Hsu12Sheng-Feng Hsu13Chun-En Kuo14Chun-En Kuo15Wen-Long Hu16Wen-Long Hu17Wen-Long Hu18Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Nursing, Meiho University, Pingtung, TaiwanDepartment of Sports Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanSchool of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, TaiwanGraduate Institute of Clinical Medical Science, China Medical University, Taichung, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanGraduate Institute of Acupuncture Science, China Medical University, Taichung, TaiwanDepartment of Chinese Medicine, China Medical University Hospital, Taipei, TaiwanDepartment of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Nursing, Meiho University, Pingtung, TaiwanDepartment of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan0Kaohsiung Medical University College of Medicine, Kaohsiung, Taiwan1Fooyin University College of Nursing, Kaohsiung, TaiwanObjective: Combinations of Chinese herbal products (CHPs) are widely used for Parkinson’s disease (PD) in Taiwan. Thereby, we investigated the use of CHPs in patients with PD.Methods: This study was a population-based cohort study that analyzed the data of patients with PD from the National Health Insurance Research Database. A total of 9,117 patients were selected from a random sample of one million individuals included in this database. We used multiple logistic regression models to estimate the adjusted odds ratios of the demographic factors and analyzed the formula and single CHPs commonly used for PD.Results: Traditional Chinese medicine users were more commonly female, younger, of white-collar status, and residents of Central Taiwan. Chaihu-Jia-Longgu-Muli-Tang was the most commonly used formula, followed by Ma-Zi-Ren-Wan and then Shao-Yao-Gan-Cao-Tang. The most commonly used single herb was Uncaria tomentosa (Willd. ex Schult.) DC., followed by Gastrodia elata Blume and then Radix et Rhizoma Rhei (Rheum palmatum L., Rheum tanguticum Maxim. ex Balf., and Rheum officinale Baill.). Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. have shown neuroprotective effects in previous studies, and they have been used for managing non-motor symptoms of PD.Conclusion: Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. are the most commonly used CHPs for PD in Taiwan. Our results revealed the preferences in medication prescriptions for PD. Further studies are warranted to determine the effectiveness of these CHPs for ameliorating the various symptoms of PD, their adverse effects, and the mechanisms underlying their associated neuroprotective effects.https://www.frontiersin.org/articles/10.3389/fphar.2020.615657/fullChaihu-Jia-Longgu-Muli-TangChinese herbal productsChinese medicineParkinson’s diseaseUncaria tomentosa (Willd. ex Schult.) DC. |