Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4
Metastatic medullary thyroid cancer (MTC) is a rare but often aggressive thyroid malignancy with a 5-year survival rate of less than 40% and few effective therapeutic options. Adoptive T cell immunotherapy using chimeric antigen receptor (CAR)-modified T cells (CAR Ts) is showing encouraging results...
Main Authors: | Vijay G. Bhoj, Lucy Li, Kalpana Parvathaneni, Zheng Zhang, Stephen Kacir, Dimitrios Arhontoulis, Kenneth Zhou, Bevin McGettigan-Croce, Selene Nunez-Cruz, Gayathri Gulendran, Alina C. Boesteanu, Laura Johnson, Michael D. Feldman, Enrico Radaelli, Keith Mansfield, MacLean Nasrallah, Rebecca S. Goydel, Haiyong Peng, Christoph Rader, Michael C. Milone, Don L. Siegel |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
|
Series: | Molecular Therapy: Oncolytics |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770521000139 |
Similar Items
-
In Vitro and In Vivo Determinations of The Anti-GDNF Family Receptor Alpha 1 Antibody in Mice by Immunochemistry and RT-PCR
by: Hossein Azizi, et al.
Published: (2020-10-01) -
Paired Expression Analysis of Tumor Cell Surface Antigens
by: Rimas J. Orentas, et al.
Published: (2017-08-01) -
GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance
by: Mihwa Kim, et al.
Published: (2018-04-01) -
LncRNA SNHG15 contributes to doxorubicin resistance of osteosarcoma cells through targeting the miR-381-3p/GFRA1 axis
by: Zhang Jinshan, et al.
Published: (2020-12-01) -
circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a
by: Rongfang He, et al.
Published: (2017-10-01)